Buffalo Bill and Wild Bill Hickock work to establish the Pony Express and fight Indians and California Separatists who seek to destroy it.

Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.—[email protected]