Pinky and the Brain are still trying to take over the world, but now they are operating from Elmyra Duff's house.

Pinky (Rob Paulsen) and the Brain (Maurice LeMarche), two genetically-enhanced laboratory mice, are still trying to take over the world. However, now that they have lost their home at Acme Labs, they are now operating from the house of the animal over-loving Elmyra Duff (Cree Summer). Now Pinky and the Brain must continually both endure Elmyra and avoid Rudy Mookich, the neighborhood bully who wants to feed them to his pet snake. Add to that a secret organization that is trying to kill the Brain just so that they can take over the world. Given all of these complications, however, Pinky and the Brain's plans still usually fail before you can say, "Troz" ("Zort" spelled backwards).—Michael "Rabbit" Hutchison <[email protected]>