"Orson Welles Great Mysteries" was a United Kingdom hosted anthology mystery and supernatural series, hosted by Orson Welles.

"Orson Welles Great Mysteries" was a twenty-six shows hosted anthology series of half hour tales of mystery and suspense from Anglia Television, that included stories by such well known authors as O Henry, Wilkie Collins and WW Jacobs, with a specially written excursion into the supernatural by the author of "Quatermass", Nigel Kneale. All episodes were introduced by Orson Welles. Actors in the series included Christopher Lee, Peter Cushing, Donald Pleasence, Joan Collins, Michael Gambon, Dean Stockwell, Hannah Gordon, Victor Buono, Susannah York, Jack Cassidy, Patrick Macnee, Joss Ackland, Geoffrey Bayldon, Bill Maynard, Megs Jenkins, Ed Devereaux, Ed Bishop, and Shane Rimmer. The haunting theme tune was provided by John Barry.—The Professor