In the Edo era during the reign of the third shogun, a mysterious smallpox epidemic affects males only, causing the number of males to plummet to one-fourth of the population. The roles of males and females are reversed. Women run businesses and politics. A young girl takes the seat as the heir of the shogunate and becomes the first female shogun. She is Tokugawa Iemitsu. When Iemitsu turns 16, the pure-hearted Madenokoji
