Rino Sakuragi is a high school student. She is good friends with Ren Kiritani who attends the same high school. They have been close since their middle school days. Rino holds special feelings for Ren, but she is unable to tell him how she feels because he is popular. One day, Ren confesses to Rino that he likes her. They begin to date and enjoy their time together, but Rino is diagnosed with ALS (amyotrophic lateral sclerosis).