Just like a comic for the big screen, "Una vez la noche" ("Once in the Night") lets us delve into the obsessions of four characters, who wander in the landscapes of their memories to tell us the fundamental events which disrupted their lives. The film is based on the accounts of four real people picked by the director, and their dreams, reinterpreted by the filmmaker with the help of four different visual artists.

Through illustrations and sounds, "Una vez la noche" ("Once in the Night") experiments with the obsessive narration of four characters, who wander in the landscapes of their memories to tell us the fundamental events that marked their lives forever.