Two unhappy strangers travel from New York to San Francisco in a rental car to partake in a scientist's radical experiment with the afterlife, but they meet people along the way who force them to confront why they are suicidal.

When a research scientist makes national news proving she can track people into the afterlife, Rose sees a way out and Teddy sees his chance to finally make it. These two strangers, both harboring dark secrets, race to join the doctor's contentious study and leave this life behind. While Rose is haunted by a ghostly presence that she can't outrun, Teddy is forced to confront his past. As these two misfits humorously quarrel their way across the country, they meet people along the way who force them to reckon with what is really driving them.