Rushi is a story of a group of medical students with aspirations to become excellent doctors and serve humanity. Having obtained a spot at the prestigious Mamata Medical College, the story portrays individuals united as friends, yet haunted by the hardships of a medical college; their daily get go, emotional crests and troughs, and sacrifices to achieve their goals. The plot thickens as Rushi, the film's protagonist, is forced to make a decision he might regret for the rest of his life.
Rushi (Aravind Krishna) is pursuing his medical education. He believes in practical thinking and is a straight-forward man. He loses his heart to his classmate Puja (Supriya Shailaja). Though Puja rejects him in the beginning, she too starts loving him later, as Puja realises that he is pursuing the doctor course not for money but to serve the people. Rushi comes across Karthik (Master Gaurav) who is battling for his life. Rushi is not a qualified doctor yet starts treatment and everyone start criticising him for taking the initiative. However, Rushi discusses with his friends about the boy''s disease and he expresses his doubt that Karthik needs heart transplant. Surprisingly, a panel of senior doctors who examine Karthik opine the same. Now, Rushi, Puja and his friends start searching for a donor. They are looking for either brain-dead or accident victims. At this juncture, the director has inserted a twist.
