After the disaster known as the Great Fart, Earth turned into a giant bum invaded by mutants. . One of the few surviving humans is a sharpie called Sheriff. He's ended up leading La Résistance, a guerrilla group fighting the monsters.

After the cataclysm known as the Big Fart, Earth has turned into a giant butt under threat of mutant invasion. Sheriff is a street-smart survivor who must turn a gang of misfits and miscreants into La Résistance, a commando squad of human warriors who can fight the mutants and save the planet.