Santino, an orphan adopted by priests, meets "Jesus in the flesh" (calls him "Bro") and gives Santino the power to heal, and the boy has a series of adventures in the fictional town of Bagong Pag-asa, helping others with their problems.

When he was just a baby, Santino was abandoned by his mother in a monastery, and he was raised there by caring priests Father Anthony, Father Jose, and Father Ringo. As a young boy, Santino finds a friend: a mysterious person he calls "Bro" (short for brother), who helps him change the lives of the people in their town. May Bukas Pa is a story that is set to open the eyes of viewers that there will always be hope amidst trials and difficulties. Miracles don't just fall from heaven but come to those who keep their faith.—Anonymous