The tragic yet entertaining story about Kasthuri, a man who is made to be sick by circumstances.

Kasthuri and Priyankara are twins. Priyankara dies of a sudden heart attack. Following the death of one of the twins, the family gets disturbed. They think that a heart attack suffered by one could affect the other too. Nadini, Kasthuri's wife who has concluded that her husband is a heart patient, imposes many a restriction on his food, journeys and his whole way of living. Though Kasthuri's mother and other relatives are acting on this 'falsehood' and worries him, Kasthuru continues with his ordinary living eating what he wants and going about as he wishes. Charith, Kasthuri's close friend tries to use the extraordinary concern by the relatives and enforced uncertain health for an ulterior motive. And he even gets a false medical report which indicates that Kasthuri is a heart patient. Now at last Kasthuri himself comes to the conclusion that he is a heart patient and his condition is deteriorating. worries about his responsibilities to his family and children. He makes arrangments for their future but Kasthuri continues to live. Meanwhile Charith tries to quicken his friend's death. Based on a true incident, the teledrama tackles a rare theme and 'Manmulawu Mama' revolves around a tragedy presented in an comic and hilarious presentation.