In the year 2067, the Tactical Sound Unit, "Walküre, " and the Valkyrie fighter team "Delta Flight, " join together to combat a disease that threatens the galaxy, the Var Syndrome.

Fifty years pass since the human race adventures to colonize the deep space, after the first war against aliens. Eight years pass after the events of Macross Frontier, between the encounter of the 25th Frontier fleet and the Vajras. Taking place in 2067, Macross Delta chronicles the events of a mysterious virus called VAR, making the host of this virus becoming incredible violent. The military assemble a Tactic Unit of Sound to eradicate the virus call Walküre, and the ones in charge of protecting this unit is the Delta Squadron. The outcome of this new war is going to affect an entire globular cumulus of planets.—ENDURO