He Chang Sheng's family had six daughters before his accidental death. Over 20 years, the sisters navigated marriage, careers, and life's challenges together, ultimately grasping their late father's emphasis on "home."

In a southern city (Huainan, Anhui), the six sisters of the He family-He Jiali, He Jiawen, He Jiayi, He Jiahuan, Liu Xiaoling, and He Jiaxi, experience a life of joy and sorrow from the 1950s to the early 21st century. The story highlights the changing roles and strengths of women amidst the shifting tides of the era, reflecting the transformation of everyday life for ordinary families in the post-establishment of New China. As the decades unfold, the six sisters face love, friendship, family ties, and career challenges, growing together and ultimately understanding the true meaning of home.

The series tells the story of He Changsheng, who, after the founding of New China, moved his family from Yangzhou, Jiangdu to settle in Huainan, Anhui, to support socialist construction. Over the next twenty years, he had six daughters, but unfortunately, he passed away in a car accident. The six sisters of the He family remain united, facing challenges together, and ultimately come to deeply understand their father's lifelong emphasis on the true meaning of "family."