A giant crocodile goes head to head with a giant anaconda. The town Sheriff must find a way to destroy the two monsters before they kill the whole town.

Jim Bickerman, the intrepid poacher and now the lucky one-eyed survivor of the reptilian attack in Lake Placid: The Final Chapter (2012), has joined forces with a pharmaceutical company, to catch a crocodile for their bizarre cross-breeding experiments. Of course, nothing goes as planned, and now, the once-fenced-off area near Maine's Black Lake is rife with ravenous crocodiles and killer anacondas, threatening to devour not only the inhabitants but also an unsuspecting team of college sorority girls. Once more, it's up to no-nonsense Sheriff Reba, along with the Fish and Wildlife officer, Will Tull, to stop the scaly menace, as the members of both aggressive species won't stop fighting until the extinction of the opponent. Is there an escape from the mandibles of death?—Nick Riganas