Adi and Sid want to make big but always run out of luck and series of confusion start taking place when they reach Goa.
The story follows Sid (Riteish Deshmukh) and Adi (Tusshar Kapoor), roommates and good friends. Adi is a struggling actor, whilst Sid is a struggling DJ who admires his own dog Sackru more than himself, Adi and Sid manage to meet ends by offering Sackru for mating in dog breeding centers where Sackru mates with female dogs of his breed on playing a specific music by Sid.Simran (Neha Sharma) and Anu (Sarah Jane Dias) are roommates. Sid is a DJ at a fashion show where Anu is a model. He mucks up the beats while Anu is on ramp, this causes Anu to trip & tear her gown which ends up exposing her breast. Anu swears revenge on Sid. Anu runs into Sid at a bar where she is a bartender. She befriends Sid and sends him to a hotel room which is occupied by cougars looking for male escorts to "service" them all night. Sid falls for Anu.
Adi meets Simran on public transport, while she is going to work. As soon as he meets her, he gets shortlisted for a b grade film "Chingum" and believes that she is his good luck charm. Adi pursues Simran & slowly they become friends. Adi falls in love with Simran who works at a call-center, Adi proposes Simran for marriage but she refuses and lies to him that she is lesbian.Then Anu and Simran go to Goa to meet Anu's father, Marlo (Anupam Kher) who has gone mad ever since the death of his mother. In Goa, Baba 3G (Chunky Pandey), a conman posing as a priest tells Marlo that his dead mother has been reincarnated into a female dog Rosemary.
When Adi and Sid take Sackru and follow the girls to Goa (basically Adi gave a ring to Simran while proposing, but forgot to take it back when she refused, and the ring had a diamond which had been gifted to Sackru by a "satisfied client". So Sid forces Adi to track Simran down to get the diamond back).Sid & Adi run into Anu and Simran respectively. To keep up the lesbian charade, Anu & Simran act as lovers.Sid meets Marlo at his home to admire his collection of bollywood movie set memorabilia. There Sackru copulates with Marlo's female dog Rosemary, whom he considers to be a re-incarnation of his mother. Marlo then believes the dog is not his mother as she was so pure and didn't let her husband touch her. However, Baba 3G, not wanting to lose his business, tells Marlo that his father has been reincarnated as Sackru, and Sackru is then kidnapped by Marlo.
Sid starts getting closer to Anu and both develop feelings for each other. Simran also witnesses the real Adi and starts realizing that he is not a weirdo. But Adi mistakenly looses Sackru at the beach. Sid is angry at Adi and believes that Marlo has kidnapped Sackru. Sid tracks Sackru at Marlo's mansion & makes a deal with Marlo to DJ the biggest party in Goa in exchange for Sackru.Sid relays the news to Anu. Till now Anu didn't know that Sackru was Sid's dog and now hates Sid for using Sackru to further his career. Meanwhile Adi opens up his heart to Simran again & professes his love to her and also says that he doesn't believe she is a lesbian. But Anu steps in & re-iterates that they are lovers & shows Adi his engagement ring, which Anu is now wearing on her fingers, to convince Adi that Anu is engaged to Simran.
Adi & Sid realize that Simran and Anu are lovers and are dejected and decide to leave Goa.Marlo decides to get Rosemary and Sackru married. Adi receives a message from Simran for help. Adi and Sid reach the venue of marriage, where Simran confirms Adi that she is not lesbian and both reunite, Sid with intent to take Sackru back plays the music on which Sackru runs on a mating spree in the function. A police inspector at the venue recognizes Baba 3G as a criminal and arrests him. The film ends with marriage of Adi, Sid and Sackru with Simran, Anu and Rosemary.