The story of the serial moves as a woman named Sivagami, falls in love with a mysterious man Aadhisheshan, who is a powerful shapeshifting snake. Sivagami and Aadhisheshan both get married and they had two girls- Jothi and Shreya. Jothi inherited human quality also snake powers and Sherya inherited the snake quality. Unaware of her shape shifting serpent powers Jothi, the Nagaloga prince's sole heir is a maid at her own palace, while enduring several hardships from evil serpent forces and her ill-treating family. How she finds her true identity, marries the love of her life and acquires the 'Nagamanickam' unravels as a mystical tale.