Crocodile file revolves around the story of husband-and-wife Hai and Nguyet. Their lives began to change when Nguyet was assigned by her leader Khanh to manage a document called "Crocodile file", a record related to the wrongdoing of Tuan, who runs a gangster group disguised as a business and is Hai's boss at the same time. The fact that Nguyet had to constantly flee from the attack from Tuan made Hai and her family unstable for a long time. The incident only ended with the participation of the criminal investigation police team led by Kim Vu and Khac Dung. Not only is the story of the criminal police breaking the case, but the film also revolves around the power struggles related to the business market share between the social factions, as well as the internal battle in the police industry. Besides, there is a blood story between sisters Nguyet - Thu and Mr. Phuong after the incident of fighting for inheritance from her mother.