'Hindi Ko Kayang Iwan Ka' follows the life of Thea Balagtas. After marrying Marco and raising their fraternal twins together, her blissful life shatters when she tests positive for HIV. Without knowing how she got it, Marco is led to believe that she cheated on him and he files for legal separation--taking their kids with him. Her disease worsens and she loses her will to live. But when she unexpectedly meets her daughter a few years later, she finds it in herself to fight more than just HIV--her greatest opponent: herself.