Garo: Makai no Hana follows Raiga Saezima, the son of Kouga Saezima and Kaoru Mitsuki, in his quest to seal the Demon Beast Eyrith, a Horror that if she blooms she will cause the Horror Messiah to return. However, he must retrieve a special tool to prepare for sealing Eyrith up once more, a tool in the possession of the mysterious girl Mayuri.
