Regina, Mac, and Warren run a game store called Game On. When the owner of the retail space decides to sell and Warren's wealthy father refuses to foot the bill, the trio must raise the money to buy the store themselves.

Game On is a coming-of-age stoner comedy that follows gamers Regina, Mac, and Warren as they struggle to find a way to save the game store they operate, or else find themselves forced to abandon their alternative lifestyle and join the "real" world.