Psychoanalyst Sigmund Freud invites professor C.S. Lewis to debate the existence of God, Freud's unique relationship with his daughter, and Lewis' unconventional relationship with his best friend's mother.

Set on the eve of WWII and towards the end of his life, Freud's Last Session sees Freud (Hopkins) invite iconic author C.S. Lewis for a debate over the existence of God. Exploring Freud's unique relationship with his lesbian daughter Anna and Lewis' unconventional romance with his best friend's mother, the film interweaves past, present and fantasy, bursting from the confines of Freud's study on a dynamic journey.