A carousing college professor's life takes a series of unimaginable turns, and all the old stories are given a new twist, when he begins to have surreal hallucinations and learns he may not be long for this world.

Inspired by the work of Leonard Cohen, and set to some of his most beloved music, Death of a Ladies' Man tells the story of a carousing college professor (Byrne) whose life takes a series of unimaginable turns, and all the old stories are given a new twist, when he begins to have surreal hallucinations and learns he may not be long for this world.