A team of miners at an outpost in deep space unearth an ancient alien artefact. After the relic is brought aboard their spaceship, the USG Ishimura, for scientific study, an alien species begins to infect the members of the ship.

The USG Ishimura, a miner spaceship, is transporting a strange artifact called the Red Marker. In the Aegis VII colony, where the Red Marker was found, there are some suicides and murders and the people are slowly going mad. The people are being infected by something. Barrow, the foreman, finds the body of his wife having committed suicide. Barrow decides to escape the colony's madness and, taking his wife's body, goes on board the Ishimura. But something happens to Barrow's wife on board the Ishimura.—Emilio Magdaleno

What seemed liked a Unitologists dream in obtaining the Marker, "The creator of all things", became a suicide mission for those aboard the USG Ishimura. As Security Officer Alissa Vincent leads a team of officers to investigate what happened in the freak mining accident below, all around the people on-board slowly become delusional homicidal maniacs. As soon is discovered, alien life has been released at the site of the Marker, and panic ensues, killing everyone in sight. A very insightful prequel as to how it all started...and how it all must end.—David Murray Arthur