Creeping Things: Desert Creepers is the second volume of a wildlife exploration series that focuses on reptiles, amphibians, insects, and arachnids collectively referred to as "creeping things" and how these animals fit into God's creation. The series follows reptile and amphibian specialist, Nathan Hutcherson, as he and his two children explore the wilderness and encounter many creeping things. In this episode they search the deserts of the Western United States and encounter: a sidewinder rattlesnake, a giant vinegaroon, a desert tortoise, a shovel-nosed snake, and other creatures. The host goes into great detail about the amazing features of each animal and how they survive and thrive.