A young woman is apprehended and held by police when they suspect that she is possessed by a demon.

After learning that a group of doctors was killed by supernatural forces, Fathers Salvador and Benedicto have their faith tested when they are tasked to perform an exorcism on a possessed woman named Clarita. Meanwhile, a photojournalist investigates the truth about Clarita's possession and helps the two priests perform the exorcism. As they try to help Clarita, they encounter demonic obstacles that prevent them from performing the exorcism.