Renegade Indians, led by Yellow Hand, are being sold guns by Donaldson. Buffalo Bill is sent to stop the arms trading and avert an Indian war.

Colonel William Cody, alias Buffalo Bill (Gordon Scott), is determined to put an end to illegal gun running between a gang of white smugglers and a Lakota Sioux named Yellow Hand. When Buffalo Bill goes to Wise Fox, the chief of Yellow Hand's tribe, and tries to convince him to sign a peace treaty with the federal troops, Yellow Fox gets wind of the plan and abducts Wise Fox's daughter, making it look like the soldiers are responsible. His deception succeeds and the Indians attack the army outpost. The only way peace can be restored is by Buffalo Bill defeating Yellow Hand in a climactic, savage, one-on one fight.—Larry B.