Dr. Sam Bliss, a medical research scientist based at Cambridge University, investigates bizarre and unexplained deaths, with the help of his assistant, Dr. Melanie Kilpatrick.

Sam Bliss and his colleague stumble upon the Duboys family. Members of this family have been known to have lived for up to 150 years, due to their special gene combination. While tracking down the remaining members of this family they find out they are not the only ones interested in the Duboys family.—Baron Friedrich von Glower