Blade, now a wanted man by the FBI, must join forces with the Nightstalkers to face his most challenging enemy yet: Dracula.
Blade finds himself alone surrounded by enemies, fighting an up hill battle with the vampire nation and now humans. He joins forces with a group of vampire hunters who call themselves the Nightstalkers. The vampire nation awakens the king of vampires Dracula from his slumber with intentions of using his primitive blood to become day-walkers. On the other side is Blade and his team manifesting a virus that could wipe out the vampire race once and for all. In the end the two sides will collide and only one will come out victorious, a battle between the ultimate vampire who never knew defeat, facing off against the greatest vampire slayer.—jay
Blade is back on his quest to rid the world of vampires. When the original vampire, Danica Talos returns, Blake is going to find his job a lot harder. Especially, when the public believe Blade is the real villain. He teams up with the daughter of Whistler, Abigail and a former vampire, Hannibal King to attempt a plan, which could destroy every vampire in existence.—Film_Fan
For the first time in his blood-soaked vampire-slaying mission, the dauntless vampire/human hybrid who possesses the best of both worlds, Blade, finds himself truly cornered, after eradicating the unstoppable menace known as the Reapers in Blade II (2002). This time, the supreme vampire assassin faces the embodiment of terror in the person of the perfect monster and humankind's arch-enemy: the resurrected Count Dracula, or Drake. Now, with his already shady reputation tainted by malicious defamation, Blade enlists the help of the young team of vampire-hunters, the Nightstalkers, who have concocted an audacious plan to rid the Earth of the parasitic bloodsuckers. However, can the "Day-walker" and his new human allies stop the King of Vampires?—Nick Riganas
As an apocalyptic event takes place that could shift the control of the planet Earth from the hands of humanity to the claws of vampires, the Daywalker, Blade is the only person who can turn the tide of the crisis against the undead blood suckers and prevent the world from becoming a "Planet of the Vampires". To make things a lot harder for Blade, the vampire leadership launches a public relations "smear campaign" against Blade, letting the world of humans know that he exists, so that the police start hunting him down, thinking he is some sort of horrible monster...—Anonymous
A group of vampires look for the hidden resting place of Drake (Dominic Purcell), also known as Dracula-the genetic "father" of their species. They find him in an Iraqi Ziggurat tomb, although not before, in a moment of blood lust, he kills one of them. The vampires capitalize on Blade's (Wesley Snipes) reputation as a serial vampire killer and frame him for the killing of a human (by making him look like a vampire). During the ensuing manhunt, the FBI locate Blade's latest hideout, and, during the siege, Abraham Whistler (Kris Kristofferson) dies (he is killed during the raid, when he decides to sacrifice his own life to protect his research and data). With his mentor gone and surrounded by human authorities, Blade allows himself to be captured and arrested.
After both medical and interrogative sessions prove futile, the police prepare to hand Blade over to a group of medics, who are, unknown to them, vampires (the vampire team comprises of Danica Talos (the vampire who awoke Drake), Asher, her brother and Jake Grimwood, the vampire strong-arm). He is rescued by Hannibal King (Ryan Reynolds) and Abigail Whistler (Jessica Biel), Abraham's daughter, both of whom belong to a group of vampire hunters called the Nightstalkers. King and Abigail reveal that the vampire Danica Talos (Parker Posey), who once temporarily turned King into a vampire, has located Drake. Because he is the first of their kind, Drake is invulnerable to sunlight. Talos hopes Drake is powerful enough to kill Blade and make the rest of the vampires into Daywalkers as well.
The Nightstalkers believe the vampires are too numerous to kill individually (They kill a few hundred each year, but the vampires are multiplying a lot faster than that), so Sommerfield (Natasha Lyonne), their resident chemical specialist, has created an experimental bio-weapon dubbed Daystar, an airborne virus capable of killing every single vampire in the world on a molecular level.
In their first confrontation, Drake tests Blade by drawing him away from King and Abigail, incapacitating King in the chaos. Although physically superior, Drake shows an affinity with Blade, as they are both unique to their race and "honorable warriors" by choice. While Drake converses with Blade, he uses a baby that he has taken hostage as leverage. Drake considers all humans unworthy of his notice and holds his own followers in contempt. Blade and Abigail learn of the vampires' planned "final solution": blood farms where brain-dead humans are harvested for their blood. Blade shuts down the victims' life support in an act of euthanasia.
The two return to find all the Nightstalkers but King and Sommerfield's young daughter, Zoe (Haili Page), dead; Drake uses the two survivors to lure Blade into combat. A posthumous recording by Sommerfield reveals that she has perfected a small quantity of the Daystar virus, but it requires the blood of Drake and may kill Blade. Meanwhile, King is chained and tortured by Jarko Grimwood (Triple H) and Asher Talos (Callum Keith Rennie) for information about Daystar. When this fails, Danica Talos, tortures King by pressuring his covered wound with the tip of the high heel of her shoe. She also threatens to turn King into a vampire again and force him to feed on Zoe.
Blade and Abigail arrive and fight the Talos' underlings and the building security force. After freeing both King and Zoe, Abigail kills Asher, King kills Jarko, and Blade engages Drake in a sword battle. In the end, Blade impales Drake with Abigail's Daystar arrow, which releases the virus into the air, killing all the nearby vampires, including Danica. As Drake dies, he praises Blade for fighting with honor and tells him that through Blade, the vampire race will survive. Dying, he offers Blade a "parting gift"; he also warns him that, "sooner or later, the Thirst always wins".
From here there are multiple endings:Theatrical ending: As Blade fought honorably, Drake gives him a "parting gift" by transforming his dying body into a replica of Blade's. The FBI retrieves the body of who they think is Blade, and thus call off their manhunt. Just as they begin the autopsy, Blade's body reverts into that of Drake's. Hannibal's voiceover tells the viewer that Blade is still alive somewhere, finishing the last struggles of the war; having rejected Drake's hopes of prolonging the vampire race, Blade's war will never end.Unrated ending: The body retrieved by the FBI is Blade's, but he's not really dead. Drake's body is nowhere to be seen, hinting at his survival. At the morgue, Blade sits up abruptly, attacks the FBI agents, and appears ready to bite a nurse on the neck. The ending is ambiguous as to whether Blade has retained his humanity or given in to his vampire thirst as Drake predicted.Werewolf ending: The Daystar virus circles the globe and wipes out all vampires. Blade walks off into the sunset, his long battle finally over. The final shot is of the Nightstalkers battling a new enemy: werewolves.
