A giant alien spider escapes from a military lab and rampages the city of Los Angeles. When a massive military strike fails, it is up to a team of scientists and one clever exterminator to kill the creature before the city is destroyed.

Once more, a failed military experiment spawns an abomination. This time, a not-so-itchy-bitchy spider finds its way into the silent morgue of an L.A. hospital, and since then, the mutated creature keeps getting bigger and bigger. Now, it's up to an unproven hero, the neighbourhood's exterminator and bug expert, Alex Mathis, to enter into the spider's mind, and save the city--and perhaps, the world--from an ever-growing menace that threatens to level everything in its path. It's hairy. It's hungry. It's the mother of all spiders. Can Alex stop the eight-legged behemoth before the U.S. Army takes over?—Nick Riganas