Follows three sisters who had other things on their minds besides their weight: such as work, relationships, popularity and starting a family.

The series follows a trio of plump siblings who had other things on their mind besides their weight: like work, relationships, popularity, and starting a family. The ladies also shared a small one-bedroom apartment in New York City, which added to the comic friction. The Gilbert sisters include Darlene (Susan Peretz), the eldest, who was a dog groomer and recently divorced (her husband had an affair with their weight loss counselor); Charlene (Wendie Jo Sperber), the middle sister, who was a make-up artist for a commercial photographer, and was the most active one out of the three; and Marlene (Lesley Boone), the youngest sister, a former toll collector (and later an actress in a pantyhose commercial and a soap opera), who was seen as a dreamer with a naive, yet trusting, personality. Also in the cast was Charlene's boyfriend, Ronnie Underwood (Rick Overton), a restaurant owner. He disappeared at mid season, as a result putting all three sisters on the dating market. At that time, the girls' landlady, Florence Newman (Nedra Volz), became a regular.

Three very different sisters share a small apartment in fast paced Manhattan, where middle sibling Charlene is upbeat with Ronnie as a boyfriend. Dog groomer Darlene is more cynical while the youngest Marlene is too innocent for the big city.