Amid the stark discord of twin cities Piltover and Zaun, two sisters fight on rival sides of a war between magic technologies and clashing convictions.

The delicate balance between the rich city of Piltover and the seedy underbelly of Zaun. Tensions between these city-states boil over with the creation of "hextech", a way for any person to control magical energy in Piltover, and in Zaun, a new drug called "shimmer" transforms humans into monsters. The rivalry between the cities splits families and friends as Arcane brings life to the relationships that shape some of League of Legends' famous champions including Vi, Jinx, Caitlyn, Jayce, Viktor, and Ekko.

In the cities of Piltover and Zaun, tensions rise as inventors, hooligans, politicians, and crime lords grow increasingly dissatisfied with the constraints of a devastated society. With the situation on the verge of being unsustainable, two sisters steal an artifact of immeasurable power. Discovery and danger collide as heroes are born and bonds are broken. Will this power change the world? Or will it lead to ruin? This is the world of Arcane.