H.H. Holmes was America's first serial killer believed to have killed nearly 200 people in the late 19th century.

The great-great-grandson of Herman Mudgett (alias H.H. Holmes - America's first serial killer), Jeff Mudgett, sets out to prove a controversial theory that H.H. Holmes and Britain's most notorious serial killer, Jack The Ripper, were the one and same man. After twenty years searching for the truth about his notorious ancestor, Mudgett partners with ex-CIA analyst Amaryllis Fox to launch an all new investigation, using 21st century science and methodology to unlock the secrets of one of the biggest cold cases of all time.—TvSeries Fan