Amanda Giese treats seemingly hopeless animals in need of a second chance, primarily focusing on dogs that others have given up on.

Amanda launches large scale rescue missions across the country to save dozens of animals that she says are "differently abled" (with major medical or special needs). She journeys to crowded California shelters that are overrun with displaced and injured animals from deadly wildfires, flies to Puerto Rico to help a dog rescue operation that needs assistance in their recovery efforts after hurricane Maria, and to Hawaii after the eruption of Kilauea to lend a helping hand. In every story, Amanda, her two kids Jade and Beast, and her partner Gary, provide a second chance to animals to get them rehabilitated and ready for adoption.