A young girl and her genius kid brother are aided by three curious witches in their search for their missing scientist father, captive of an omnipotent otherworldly villain simply called 'It' whose evil is slowly infecting the universe.

Meg and Charles Wallace are aided by Calvin and three interesting women, Mrs. Which, Mrs. Whatsit, and Mrs. Who in the search for their father who disappeared during an experiment he was working on for the government. Their travels take them around the universe to a place unlike any other. They must learn to trust each other and to understand that everyone is different.—Mandy Heuer

World-renowned physicist Dr. Jack Murray and his lab assistant Hank are experimenting with 5th dimension time travel when they suddenly disappear. Several months after this mysterious event, Dr. Murray's children - Meg and Charles Wallace - have had no news. Then, suddenly, they and their neighbour Calvin O'Keefe are summoned by strange forces to find the missing physicist. The trio begin a search to find their dad and his assistant.—Toronto Children's Film Festival