- Matthew Labyorteaux
-  Jaden Yuki / ... 180 episodes, 2004-2008
                    
- Wayne Grayson
-  Syrus Truesdale / ... 118 episodes, 2004-2007
                    
- Tony Salerno
-  Chazz Princeton / ... 83 episodes, 2004-2006
                    
- Sean Schemmel
-  Vellian Crowler / ... 80 episodes, 2004-2007
                    
- David Wills
-  Tyranno Hassleberry / ... 70 episodes, 2004-2007
                    
- Kanako Irie
-  Johan Anderson 73 episodes, 2006-2008
                    
- Eric Stuart
-  Bastion Misawa / ... 66 episodes, 2004-2007
                    
- Christie Moreau
-  Alexis Rhodes 55 episodes, 2005-2007
                    
- Marc Thompson
-  Chazz Princeton / ... 51 episodes, 2004-2007
                    
- Emlyn Elisabeth Morinelli
-  Alexis Rhodes 52 episodes, 2005-2007
                    
- Ted Lewis
-  Chumley Huffington / ... 51 episodes, 2004-2006
                    
- Scott Rayow
-  Zane Truesdale / ... 51 episodes, 2004-2007
                    
- Christopher Collet
-  Conklin / ... 43 episodes, 2004-2006
                    
- Lisa Ortiz
-  Ms. Dorothy / ... 42 episodes, 2004-2006
                    
- Madeleine Blaustein
-  Sartorius / ... 39 episodes, 2004-2007
                    
- Suzanne Goldish
-  Jasmine / ... 31 episodes, 2004-2006
                    
- Erica Schroeder
-  Sarina / ... 30 episodes, 2004-2006
                    
- Darren Dunstan
-  Maximillion Pegasus / ... 28 episodes, 2004-2007
                    
- Oliver Wyman
-  Aster Phoenix / ... 27 episodes, 2005-2007
                    
- Cassandra Lee Morris
-  Yubel / ... 25 episodes, 2006-2007
                    
- Priscilla Everett
-  Alexis Rhodes 23 episodes, 2004-2005
                    
- Clay Adams
-  Tyranno Hassleberry / ... 23 episodes, 2005-2007
                    
- Mike Pollock
-  Jean-Louis Bonaparte / ... 21 episodes, 2004-2007
                    
- Jason Griffith
-  Atticus Rhodes / ... 21 episodes, 2005-2007
                    
- Kerry Williams
-  Sadie / ... 20 episodes, 2004-2005
                    
- Takehito Koyasu
-  Takuma Saiou 16 episodes, 2005-2006
                    
- Gregory Abbey
-  Damon / ... 14 episodes, 2004-2006
                    
- Samira Fernandes
-  Alexis rhodes 13 episodes, 2008
                    
- Jonathan Todd Ross
-  Slade Princeton / ... 9 episodes, 2004-2005
                    
- Liza Jacqueline
-  Blair Flannigan / ... 9 episodes, 2005-2007
                    
- Duane Cooper
-  Axel Brodie 9 episodes, 2006-2007
                    
- Veronica Taylor
-  Crystal Beast Amethyst Cat / ... 5 episodes, 2005-2007
                    
- Erik Singer
-  Jim Crocodile Cook 8 episodes, 2006-2007
                    
- Matt Hoverman
-  Student 5 6 episodes, 2005
                    
- Tom Wayland
-  Abidos the Third / ... 4 episodes, 2005-2006
                    
- Jamie McGonnigal
-  Skilled Dark Magician / ... 4 episodes, 2007
                    
- Marc Diraison
-  Chancellor Foster 3 episodes, 2005
                    
- Kathleen Delaney
-  Tania 3 episodes, 2005-2007
                    
- Andrew Rannells
-  Belowski / ... 3 episodes, 2005-2006
                    
- Dan Green
-  Guardian of the Labyrinth / ... 3 episodes, 2005-2007
                    
- David Moo
-  Gravekeeper's Chief 2 episodes, 2005
                    
- Cliff Gulibert
-  Kyle 2 episodes, 2005
                    
- Maki Saito
-  Téa Gardner 1 episode, 2008
                    
- Shunsuke Kazama
-  Yami Yugi / ... 1 episode, 2008
                    
- Trevor Forsman
-  Chick the Yellow 1 episode, 2005
                    
- Sebastian Arcelus
-  Marcel Bonaparte 1 episode, 2007
                    
- Brian Maillard
-  Gerard (uncredited) 2 episodes, 2005
                    
- Michael Sinterniklaas
-  Torrey (uncredited) 1 episode, 2005
                    
- Jesse Hooker
-  Blaze (uncredited) 1 episode, 2006