- Kristen Wiig
- Alice Klieg
- Wes Bentley
- Gabe Ruskin
- Linda Cardellini
- Gina Selway
- Joan Cusack
- Dawn Hurley
- Loretta Devine
- Barb Vaughn
- Jennifer Jason Leigh
- Deb Moseley
- Thomas Mann
- Rainer Ybarra
- James Marsden
- Rich Ruskin
- Tim Robbins
- Dr. Daryl Moffet
- Alan Tudyk
- Ted Thurber
- Kulap Vilaysack
- Grace Dao
- Mitch Silpa
- Derek
- Anelia Dyoulgerova
- Magda
- Joe Roland
- Technical Director
- Joyce Hiller Piven
- Miriam Klieg
- Jack Wallace
- Bud Klieg
- Rose Abdoo
- Connie
- Hannah Chodos
- Alice Re-Enactor #1
- Sabra Williams
- Alice Re-enactor #2
- Charlote Barstow
- Alice Re-enactor #3
- Shanna Strong
- Alice Re-enactor #4
- Tanya Reese
- Alice Re-enactor #5
- Tara Copeland
- Gina Re-enactor #1
- Polly du Pont Noonan
- Gina Re-enactor #2
- Lauren Katz
- Jordana Re-enactor
- Kevin Brewerton
- Lifeguard Re-enactor
- Lawrence Grimm
- Male Customer
- Jessica Lee Williamson
- Woman in Van
- Steve Bethers
- Hotel Security Officer
- Anthony Bravo
- News Anchor
- Isa Freeling
- Lottery Announcer
- Donna Jo Thorndale
- Constant Fan
- George Basil
- Technical Director #2
- Jeremy Piven
- Additional Voices
- Drew Brooks
- Additional Voices
- Spencer Kayden
- Additional Voices
- Oprah Winfrey
- Self
- Maame-Yaa Aforo
- Dr. Daryl's Wife
- Ethan Aronoff
- Undetermined Secondary Role
- Sybil Azur
- Undetermined Secondary Role
- Joanna Bloem
- Undetermined Secondary Role
- Eric Bruno Borgman
- Undetermined Secondary Role
- Brad Calcaterra
- Undetermined Secondary Role
- Cindera Che
- Undetermined Secondary Role
- Elizabeth Duff
- Undetermined Secondary Role
- Julia Effertz
- Jordana Re-enactor
- Kelsey Farrar
- Undetermined Secondary Role
- CB Ferrari
- Undetermined Secondary Role
- Thomas Fiss
- Undetermined Secondary Role
- Sommer Garcia
- Undetermined Secondary Role
- Dieterich Gray
- Doctor Re-enactor
- Phil Hawn
- Undetermined Secondary Role
- Doug Anthony Jones
- Telethon Usher
- Brian Kirchoff
- Undetermined Secondary Role
- Mike Knox
- Undetermined Secondary Role
- Morgan Larson
- Undetermined Secondary Role
- Meghan McLeod
- Undetermined Secondary Role
- Jody Millard
- Undetermined Secondary Role
- Nicole Mills
- Undetermined Secondary Role
- Mary Eileen O'Donnell
- Mean Looking Matron
- Phil Parlapiano
- Undetermined Secondary Role
- Rachel Reedy
- Undetermined Secondary Role
- Olivia Rosewood
- Undetermined Secondary Role
- Sandra Rosko
- Undetermined Secondary Role
- Melody Ruetsche
- Sidney / Concession Worker (uncredited)
- Chala Savino
- Nurse Re-enactor
- Lisa Shields
- Mother
- Laura Faye Smith
- Undetermined Secondary Role
- Amani Starnes
- Alice Re-enactor Watching TV in Finale
- Ben Tanguay
- Shopper
- Eric Alan Wendell
- Undetermined Secondary Role
- Peter John White
- Undetermined Secondary Role
