- Nat Faxon
- Awards Show Stage Manager
- John C. Reilly
- Dewey Cox
- Tim Meadows
- Sam
- Conner Rayburn
- Dewey Age 8
- Chip Hormess
- Nate
- Raymond J. Barry
- Pa Cox
- Terrence Beasor
- Country Doctor
- Margo Martindale
- Ma Cox
- Honeyboy Edwards
- Old Bluesman
- Gerry Black
- Harmonica Player
- Aron Johnson
- Teenage Band
- Jack Donovan Saperstein
- Teenage Band
- Taylor Hubert
- Teenage Band
- Christopher Hurt
- Teenage Band
- Matt Price
- MC (Teacher)
- John Maynard
- Man at Talent Show
- E.J. Callahan
- Second Man at Talent Show
- Rance Howard
- Preacher
- Kristen Wiig
- Edith
- Craig Robinson
- Bobby Shad
- Paul Bates
- Nightclub Manager
- Patrick Faucette
- Bad Men Bass Player
- Harold Ramis
- L'Chaim
- Phil Rosenthal
- Mazeltov
- Martin Starr
- Schmendrick
- Oscar Dillon
- Audience Guy at Nightclub
- Chris Parnell
- Theo
- Matt Besser
- Dave
- Jack McBrayer
- DJ
- Molly C. Quinn
- Teen with Pinups
- John Ennis
- The Big Bopper
- Frankie Muniz
- Buddy Holly
- Ed Helms
- Stage Manager
- Jack White
- Elvis Presley
- Angela Little
- Beth Anne
- Odette Annable
- Reefer Girl
- Tyler Nilson
- Bert
- Jenna Fischer
- Darlene Madison
- Deanna Brooks
- Hotel Groupie with Dewey
- Ian Roberts
- Drug Dealer
- Steve Bannos
- Prison Guard
- Willow Geer
- Rehab Nurse
- David Doty
- Rehab Doctor
- Jack Kehler
- Press Conference Reporter
- Gerry Bednob
- The Maharishi
- David Krumholtz
- Schwartzberg
- Tim Bagley
- Engineer
- Jane Lynch
- Gail the Television Reporter
- Skyler Gisondo
- Dewdrop
- Kshitij Pendurkar
- Dewey Rahim
- Simon Helberg
- Dreidel L'Chaim
- Jacques Slade
- Lil' Nutzzak
- Danica Rozelle
- Music Video Girl
- Lurie Poston
- Cox Kid
- Maggie Mannion
- Cox Kid
- Jackson Browne
- Jackson Browne
- Jewel
- Jewel Kilcher
- Lyle Lovett
- Lyle Lovett
- Stacey Scowley
- Pierced Eyebrow Girl
- Ajla Hodzic
- Pierced Lip Girl
- Ghostface Killah
- Ghostface Killah
- Otis Williams
- The Temptations
- Ron Tyson
- The Temptations
- Terry Weeks
- The Temptations
- Joe Herndon
- The Temptations
- Bruce Williamson
- The Temptations
- Eddie Vedder
- Eddie Vedder
- AJ Abaya
- Dewey's Grandson
- Don Abernathy
- Pygmy Bushman / Man in 50's Club (uncredited)
- Patrick J. Adams
- The Kid
- Robert Amjarv
- Theremin Player
- Marie Antoinette
- Red Carpet Guest
- George Anton
- Hotel Groupie
- Michael William Arnold
- Dewey's Kid 1970
- Isabella Astor
- Dewey's Daughter
- Christopher Ausburn
- Grandson
- Laila Ayad
- Backstage Elvis Groupie
- Caleb Babcock
- Dewey's Son
- Katrina Baker
- Dewey Fan
- Sydney Hope Banner
- Daughter
- Jay Bird
- Caveman
- Rian Bishop
- Concert Patron
- Jack Black
- Paul McCartney
- Clement Blake
- Edith's Father
- Chris Blount
- Dewey Cox's Son - Playing Ball
- Ian Bodell
- Son
- Deborah Britton
- Fan
- David Burrus
- Kid #1
- D.T. Carney
- Concert Patron
- Michael Chanslor
- Recording session pianist
- Paula Christensen
- Backstage Elvis Groupie
- James Collins
- Man in Dream
- John D. Crawford
- Officer Clark
- Madison Cruz
- Hotel Groupie
- Jen Curci
- Sara Parker
- Vince Cusimano
- Frowning Hippie
- Rose Davidson
- Dewey Cox Fan
- Marty Dew
- Dancer
- Aubrey Dickinson
- 1950's Girl
- Sally Digirolamo
- 1950s Girl
- Johnny Drocco
- Dude Seated in Stands
- Olivia Taylor Dudley
- Pot Smoker
- Patrick Duffy
- Patrick Duffy
- Holly Dunlap
- 60's Protestor
- Jayne Eastwood
- 70's Girl
- Bob Emmet
- Band Pianist
- David Miguel Estrada
- 50's Soc Guy
- Keith Ewell
- Angry Bar Patron
- Morgan Fairchild
- Morgan Fairchild
- Sommer Fehmel
- 1952 Groupie
- Paul Feig
- Different DJ
- Amy Ferguson
- Teenager
- Jennie Ford
- Dewey Cox Show Dancer
- Monica Ford
- Hotel Groupie
- Gregory George Frank
- Parent / Stagehand (uncredited)
- London Freeman
- Dewey Cox's Daughter
- Geoffrey Gould
- Sound Engineer
- Alice Greenfield
- Teen Fan
- Jennifer Lana Harper
- Cox girlfriend
- Danielle E. Hawkins
- Music Video Dancer
- Amber Hay
- LSD Vision
- Matthew Herington
- Hippie with Guitar
- Adam Herschman
- Jerry Garcia
- Hedwig Herzog
- Girlfriend
- John Michael Higgins
- Record Producer
- Jonah Hill
- Older Nate
- Neil Ironfield
- Dewey's Child
- Stephen Janousek
- Concert Patron #2
- Norma Jean
- Punk Rocker
- Dave Johnson
- Stagehand
- Kayla Kalisz
- Birthday Party Guest
- Alexander Kaminer
- Theater Patron
- Stephanie Katz
- Hotel Groupie with Dewey
- Scarlett Keegan
- Fiddle Player
- Alvin Knight Sr.
- Pygm Bushman
- Rowena Koenig
- Hotel Groupie #4
- Monique La Barr
- Back-up Singer
- Alvaro Laborin
- Mulatto / Hippie Protester (uncredited)
- Cheryl Ladd
- Cheryl Ladd
- Frederick Lawrence
- Stagehand
- Amanda Leak
- Hotel Groupie
- Gregg Lee
- Concert Attendee
- Lisa Mason Lee
- Sam's Groupie
- Rae Sunshine Lee
- Concert Attendee
- Hannah Leigh
- Dewey's Little Sister
- Justin Long
- George Harrison
- Amy Main
- Backup Singer
- Frances Manzo
- Dancer
- Devinna Marcelina
- Flasher
- Eddie Mariano
- Concert Patron
- Samantha Mason
- Teen Fan
- Oscar McFarlane
- Pygmy Bushman
- Rosalie Miller
- 1970s Girl
- Talia Montgomery
- Hotel Groupie #5
- Dawn Morrow
- Dancer
- Kazu Nagahama
- Taiko Drum Performer
- Vernon Neilly
- Bobby Shad Band Member
- Sarah Christine Pletcher
- 1960s Protester
- Chris Rossi
- Dancer
- Paul Rudd
- John Lennon
- Franklin Ruehl
- Junkie
- Kayla Sanders
- Tap Dancer
- Alif Sankey
- Dancer
- Jason Schwartzman
- Ringo Starr
- Julia Stephens
- Teen Fan
- Shane Stephenson
- Child at Party
- Tony Swift
- Backstage Crew
- Serria Tawan
- 70's African American Woman
- Cheryl Tiegs
- Cheryl Tiegs
- Cristina Trevino
- Red Carpet Guest
- Briana Venskus
- Marching Mullato
- Madison Victoria
- Granddaughter
- Christian Vincent
- Dancer
- Haleigh Ward
- Dewey's Daughter
- George F. Watson
- Photographer at Band Photo Session
- Jacob White
- Teenage Band Member
- Matthew Witmer
- Musician
- Debbie Yeh
- Asian Woman 70's
- Waneeki Yokomee-Fung
- Concert Patron
- Maria Zambrana
- Theatergoer
