- Gary Cooper
- Capt. Christopher Holden
- Paulette Goddard
- Abby
- Howard Da Silva
- Garth
- Boris Karloff
- Guyasuta - Chief of the Senecas
- Cecil Kellaway
- Jeremy Love
- Ward Bond
- John Fraser
- Virginia Campbell
- Mrs. John Fraser
- Katherine DeMille
- Hannah
- Henry Wilcoxon
- Capt. Steele
- C. Aubrey Smith
- Lord Chief Justice
- Victor Varconi
- Capt. Simeon Ecuyer
- Virginia Grey
- Diana
- Mike Mazurki
- Dave Bone
- Porter Hall
- Leach
- Richard Gaines
- Col. George Washington
- Gavin Muir
- Lt. Fergus McKenzie
- Jane Nigh
- Evelyn
- Alan Napier
- Sir William Johnson
- Marc Lawrence
- Sioto - Medicine Man
- Raymond Hatton
- Venango Scout
- John Mylong
- Col. Henry Bouquet
- George Kirby
- Charles Mason - London Astronomer
- Leonard Carey
- Jeremiah Dixon - London Astronomer
- Frank Wilcox
- Richard Henry Lee
- Davison Clark
- Mr. Carroll - of Virginia
- Griff Barnett
- Brother Andrews - of Pennsylvania
- Lloyd Bridges
- Lt. Hutchins
- Oliver Thorndike
- Lt. Baillie
- Ninetta Sunderland
- Mrs. Pruitt
- Rus Conklin
- Mamaultee
- Iron Eyes Cody
- Red Corn
- Julia Faye
- Widow Swivens
- Paul E. Burns
- Dan McCoy
- Mary Field
- Maggie
- Diane Wadelow
- Lancashire Lass
- Clarence Muse
- Jason
- Eddie Albert
- Barker
- Robert Barron
- Surveyor
- John Goldsworthy
- Policeman
- Charles Middleton
- Mulligan
- Henry Mowbray
- Policeman
- Jerry Warren
- Villager
- Robert Warwick
- Pontiac - Chief of the Ottawas
- Dorothy Adams
- Woman Beside Garth Happy at Bagpipes
- Victor Adamson
- Citizen
- Mimi Aguglia
- Squaw
- Eric Alden
- Zeke / Indian (uncredited)
- Erville Alderson
- Grizzled Codger at Ball Saying 'May Be Long Visit'
- Richard Alexander
- Slave
- George Anderson
- Villager
- Beulah Archuletta
- Seneca Woman
- Sam Ash
- Villager
- William Bailey
- Villager
- Walter Baldwin
- Villager
- Trevor Bardette
- Villager Beside Garth at Ft. Pitt Siege
- Lex Barker
- Royal American Officer
- Valmere Barman
- Girl at Whipping Post
- Chief John Big Tree
- Indian
- Arthur Blake
- Aristocrat
- Matthew Boulton
- Capt. Brooks
- Al Bridge
- Militiaman at Fair
- George Bunny
- Villager
- Dwight Butcher
- Guard
- James Carlisle
- Villager
- Lane Chandler
- Member of Court-Martial Board
- Maxine Chevalier
- Squaw
- Robin Sanders Clark
- Ben
- Russ Clark
- Officer
- Jack Rube Clifford
- Frontiersman
- Fred Coby
- Royal American Soldier
- J.W. Cody
- Lesser Indian Chief
- Clancy Cooper
- Sentry
- Dimples Cooper
- Squaw
- Harry Cording
- Garth's Marksman
- Jeff Corey
- Trapper
- Donna Courter
- Woman
- Willa Pearl Curtis
- Mammy
- Fred Datig Jr.
- Man
- Boyd Davis
- Dr. Boyd
- Donya Dean
- Villager
- Edgar Dearing
- Soldier in Gilded Beaver
- Cecil B. DeMille
- Narrator
- Leslie Denison
- Bailiff
- Jim Drum
- Villager
- Claire Du Brey
- Squaw
- Eddie Dunn
- Frontiersman
- Eugene Eberle
- Drummer Boy
- Fernanda Eliscu
- Squaw
- Richard Elmore
- Officer
- Jane Everett
- Villager
- Betty Farrington
- Villager
- Al Ferguson
- 'Star of London' Crewman
- Budd Fine
- Man in Boat
- James Flavin
- Villager
- Charles Flynn
- Ens. Price
- Francis Ford
- Frontiersman on Fort Pitt Roof
- Byron Foulger
- Townsman
- Kenneth Gibson
- Villager
- Arthur Gould-Porter
- Court Clerk
- Greta Granstedt
- Woman
- Beatrice Gray
- Woman
- Ethel Greenwood
- Party Guest
- Karolyn Grimes
- Little Girl
- William Haade
- Trapper at Ball
- Frank Hagney
- Jake - Bartender
- Bill Hale
- Corporal
- Chuck Hamilton
- Villager
- Alec Harford
- Bandit Bond Slave
- Charmienne Harker
- Squaw
- John Harmon
- Spieler for Monster of Madagascar
- June Harris
- Frontierswoman
- Len Hendry
- Indian Trapper
- Rose Higgins
- Squaw
- Earle Hodgins
- Spieler for Mermaid
- Leyland Hodgson
- Jailer
- Michael Hordern
- Court Bailiff
- James Horne Jr.
- Royal American Officer
- Bill Hunter
- Sentry
- Olaf Hytten
- Officer on 'Star of London'
- Boyd Irwin
- Passenger
- Jerry James
- Villager
- John James
- Officer at the Ball
- Si Jenks
- Farmer at the Fair
- Noble Johnson
- Tall Ottawa Shot at Gilded Beaver
- Tiny Jones
- Bondswoman
- Llorna Jordon
- Villager
- Colin Kenny
- Jailer
- Crauford Kent
- Chaplain
- Mike Killian
- Virginia Militia Officer
- Fred Kohler Jr.
- Sergeant
- Bob Kortman
- Frontiersman / Indian (uncredited)
- Mike Lally
- Trapper at Fort Pitt
- Hope Landin
- Joshua's Mother
- Wallace Earl Laven
- Slave
- Larry Lawson
- Trapper
- Jack G. Lee
- Maj. Trent
- Anna Lehr
- Woman
- George Magrill
- Ship's Agent
- John Mallon
- Trapper
- Ted Mapes
- Villager - Fort Pitt Defender
- Carl Mathews
- Indian Trapper
- Francis McDonald
- Frontiersman
- William Meader
- Bond Slave
- John Merton
- Sentry at Ball Denying Chris Exit
- John Miljan
- Prosecutor at Court-Martial
- Harlan Miller
- Villager
- Belle Mitchell
- Squaw
- Bert Moorhouse
- Virginia Militia Officer
- Frank Moran
- Tom - Coarse Slave Seeking Rich Widow
- Barbara Morrison
- Passenger
- Al Murphy
- Villager
- William Murphy
- Villager
- Ottola Nesmith
- Woman
- James Nolan
- Villager
- John Northpole
- Frontiersman
- Jack Overman
- Sentry
- Inez Palange
- Squaw
- Jasper Palmer
- Villager
- Jack Pennick
- Joe Lovat
- Edvard Persson
- Indian
- Lee Phelps
- Member of Court-Martial Board
- Hugh Prosser
- Soldier in Gilded Beaver
- Constance Purdy
- Mother at the Ball
- David Ralston
- Royal American Officer
- Sally Rawlinson
- Brunette
- Allan Ray
- Soldier
- Rodd Redwing
- Indian
- Richard Reeves
- Joshua
- Gordon Richards
- Sheriff
- Buddy Roosevelt
- Guard at the Ball
- Louise Saraydar
- Woman
- Carl Saxe
- Villager
- Syd Saylor
- Spieler for Dr. Diablo
- Tonio Selwart
- Slave Buyer at Fair
- C. Montague Shaw
- Judge's Aide
- Jay Silverheels
- Indian
- Ray Spiker
- Frontiersman
- Charles Sullivan
- Trapper
- William Sundholm
- Frontiersman
- Gus Taute
- Royal American Officer
- Forrest Taylor
- Shopkeeper at the Ball
- Ray Teal
- Soldier in the Gilded Beaver
- Larry Thompson
- Officer
- Chief Thundercloud
- Chief Killbuck
- Gertrude Valerie
- Woman
- Nanette Vallon
- Squaw
- Dorothy Vernon
- Party Guest
- Charles Victor
- Officer
- Bess Wade
- Villager
- Ethel Wales
- Villager
- Geraldine Wall
- Mrs. Bitt
- Bill Wallace
- Villager
- Fred Walton
- Minor Role
- Jack Weatherwax
- Assistant Medicine Man
- Joe Whitehead
- Villager
- Crane Whitley
- Plantation Master at the Fair
- Lloyd Whitlock
- Passenger
- Guy Wilkerson
- Frontiersman
- Gilbert Wilson
- Royal American Officer
- Jeff York
- Wide-Shouldered Bond Slave
- Fred Zendar
- Trapper
