- Snoop Dogg
- Major LeGrande Bushe
- Garrett Wang
- Dr. Charles Hunter
- Chase Masterson
- Captain Connie Garrison / Natasha
- Tim Russ
- Dr. Robert Schmitt
- Kevin Carlson
- Captain Kirk Stillwood
- Nichelle Nichols
- Sensei / Aunt Petunia
- Robert Picardo
- Edgar Allen Putz / Boris / Award Show Presenter / Dr. Nontu Soon
- Marina Sirtis
- Award Show Presenter
- Michael Dorn
- Dr. Deystrum
- Nana Visitor
- Dr. Samantha Stamen
- Walter Koenig
- Fireman Frank
- Linda Park
- Amber Earhardt
- Connor Trinneer
- Captain Jack Youngblood
- Michael Madsen
- President Ben Dover
- Robert Davi
- The Gardener of Frickin' Forever
- Manu Intiraymi
- Private Durwood
- Angelique Fawcette
- Lynn Hastings / Afro Agent / Nurse Uri / Don Gornelius Jr. / Nay Nay / Tay Tay / Cow / Dodo The 'Big Bang' Bean (voice)
- Katarina Van Derham
- Captain Cheryl Stillwood
- Dina Meyer
- Female Moesha
- Olivia d'Abo
- Female Larrisha
- Julie Warner
- Female Curlisha
- Armin Shimerman
- Male Moesha
- Jeffrey Combs
- Male Larrisha
- John Billingsley
- Male Curlisha
- Dominic Keating
- Hacky
- Max Grodénchik
- Paramedic Yacky
- Casey Biggs
- Detective Dan Marr
- Brenda Bakke
- Nurse Christine Choppel
- Patti Yasutake
- Dr. Beverly Krasher
- McKenzie Westmore
- Self
- Gilbert Gottfried
- Self
- Anthony Montgomery
- The Launchman
- Vaughn Armstrong
- Russell Sprout
- Gary Graham
- Neil Downe
- Steve Rankin
- Dr. Len McCoyy
- Michael Dante
- Michael Dante
- Jack Donner
- Jack Donner
- Michael Forest
- Michael Forest
- Sean Kenney
- Sean Kenney
- Gary Lockwood
- Gary Lockwood
- BarBara Luna
- BarBara Luna
- Beverly Washburn
- Beverly Washburn
- Celeste Yarnall
- Celeste Yarnall
- Bobby Clark
- Don Gornelius
- Jasmine Jessica Anthony
- Eileen Dover
- Crystal Allen
- Jasmine
- Menina Fortunato
- Rose
- Christopher Doohan
- Engineer Scootie Montgomery
- Deprise Brescia
- Daisy
- Rosamund Rinehart
- Laura Luzair
- Anne McDaniels
- Anne Droid
- Brooke Newton
- Ramora
- Emily L. Stanton
- Emily L. Stanton
- Guy Nardulli
- Apollo
- Steven Scot Bono
- Buzz The Pothead
- Peter Tedeschi
- Budd The Pothead
- Seth Austin
- Harold The Herald
- John Hafner
- ATC Officer Roger Thompson
- Brit Navarro
- Tatty Tayle
- Stevie Waichulis
- Hammy The Hamster / Bystalker Flower (voice) (as Stephen Waichulis)
- Sam Asghari
- Sam Asghari
- Casper Smart
- Casper Smart
- Jeffrey Dinsdale
- Film Set Security Guard
- Mitch Alcala
- Riley Finn
- Angelique Kenney
- Blonde Selfie Girl
- Nadia Lanfranconi
- Nadia Lanfranconi
- Royee Shen
- Young Attendant #1
- Vincent Shen
- Young Attendant #2
- Buster Pelster
- Alien
- Moses Castaneda
- Alien
- Bert Rotundo
- Alien
- Steven L. Fawcette
- Captain Buttok Snortz
