- John Oates
- Self (Segment "Reunion Party")
- Thomas Lyons
- Dave Bertman (Segment "Reunion Party")
- Craig Shoemaker
- Self - Narrator (Segment "Reunion Party")
- Heather Sossaman
- Gina Marie (Segment "Reunion Party")
- Chris Dollard
- Gizmo Gouda (Segment "Reunion Party")
- Kelly Perine
- Skip (Segment "Reunion Party")
- Michelle Stafford
- Ex-Wife Jessica (Segment "Reunion Party")
- Dale Midkiff
- Doug (Segment "Reunion Party")
- Sharon Amos
- Stephanie (Segment "Reunion Party")
- Brooke Hasalton
- Debater Judith (Segment "Reunion Party")
- Dennis Luciani
- Debater 'Hula' (Segment "Reunion Party")
- Jayden Lund
- Debater Maurice (Segment "Reunion Party")
- Rich Hardisty
- Debater Rich (Segment "Reunion Party")
- Dale Dudley
- Debater 'Noid' (Segment "Reunion Party")
- Bob Fonseca
- Debater Bob (Segment "Reunion Party")
- Michael Ralph
- Debater Steve (Segment "Reunion Party")
- Lola Davidson
- Stripper Barbie (Segment "Reunion Party")
- Blossom Thorndike
- Stripper Candie (Segment "Reunion Party")
- Daisy Tormé
- News Reporter(Segment "Reunion Party")
- Masha Zeeva
- Sister Mary (Segment "Reunion Party")
- Christy Patrick
- Sister Maria (Segment "Reunion Party") / Martha's Daughter (Segment "Mudslingers")
- Gregg Buskett
- Lone Pot Activist (Segment "Reunion Party")
- Matt Armor
- Robbie "Rock Cock" (Segment "Reunion Party")
- Jesse Rambis
- Gina's Guy Nick (Segment "Reunion Party")
- Sean Wise
- Gina's Guy #2 (Segment "Reunion Party")
- Josh Megdell
- Background Cop (Segment "Reunion Party")
- Shaun Thomas
- Background Cop #2 (Segment "Reunion Party")
- Ari Rutenberg
- Street 'John' (Segment "Reunion Party")
- Brandon Conners
- Pizza Delivery Guy (Segment "Reunion Party")
- Charlie Hodge
- Debater Charlie (Segment "Reunion Party")
- Jiazi Wang
- 'Pot-Tub' Chick (Segment "Reunion Party") / Asian Hot Babe (Segment "FunOnion Boardroom")
- Steve Hytner
- Hack Murphy (Segment "Mudslingers")
- Roma Maffia
- Dr. Willa Peterson (Segment "Mudslingers")
- Tim Bagley
- Rusty Polten (Segment "Mudslingers")
- Elizabeth Hayden
- Martha Hallworth (Segment "Mudslingers")
- Rustam Branaman
- Producer (Segment "Mudslingers")
- Ivar Brogger
- Reverend Finkle (Segment "Mudslingers")
- Michael Oden
- Producer Daryl (Segment "Mudslingers")
- Stephen Tobolowsky
- Jesco Rollins (Segment "American Farmer")
- Lilli Passero
- Jesco's Teen Daughter (Segment "American Farmer")
- Justin Shoemaker
- Jesco's Young Boy (Segment "American Farmer")
- Izabella Passero
- Jesco's Young Daughter (Segment "American Farmer")
- Daniel Buskett
- Jesco's Son (Segment "American Farmer")
- Max Weinberger
- Farm Hand #1 (Segment "American Farmer")
- James Fraijo
- Farm Hand #2 (Segment "American Farmer") / DEA Man Meat #7(Segment "Cooking with Martha")
- William Atherton
- Mr. Lyle Funonion (Segment "FunOnion Boardroom")
- Danny Nucci
- Arturo Goldman (Segment "FunOnion Boardroom")
- Dave Erickson
- Board Member Jack (Segment "FunOnion Boardroom")
- Tim Stearns
- Board Member Sanderson (Segment "FunOnion Boardroom")
- Sara Ballantine
- Board Member Sherri (Segment "FunOnion Boardroom")
- Eric Lawson
- Board Member James (Segment "FunOnion Boardroom")
- James Kiriyama-Lem
- Asian Board Member (Segment "FunOnion Boardroom")
- Ralph Ting
- Moustachio (Segment "FunOnion Boardroom") / Darren (Segment "Diff'rent Tokes")
- Ant
- Reginald Stevens (Segment "Smoke Pot not C**k")
- Jordan Garrett
- Stanley (Boy #1) (Segment "Smoke Pot not C**k")
- Adam Cagley
- Johnny (Boy #2) (Segment "Smoke Pot not C**k")
- Tom Sprague
- Bible Belt Father (Segment "Smoke Pot not C**k")
- Jeri Zucchi
- Bible Belt Mother (Segment "Smoke Pot not C**k")
- Jeffery Passero
- Dee-Wayne (Segment "Smoke Pot not C**k")
- Lee Abbott
- Director (Segment "Smoke Pot not C**k")
- Ellis Williams
- Dad (Segment "Diff'rent Tokes")
- Marsha Clark
- First Lady Swanson (Segment "Diff'rent Tokes")
- Craig X. Rubin
- Pro Pot Advocate (Segment "Diff'rent Tokes")
- Kane Ritchotte
- Mikey (Segment "Diff'rent Tokes")
- Trevor Duke-Moretz
- Todd (Segment "Diff'rent Tokes")
- Mark Thompson
- Secret Service Agent #1 (Segment "Diff'rent Tokes")
- Brian Phelps
- Secret Service Agent #2 (Segment "Diff'rent Tokes")
- Alonzo Bodden
- Johnny Buskett (Segment "Way Inside Sports")
- Jerry Penacoli
- Thomas (Segment "Way Inside Sports")
- Marianne Curan
- Martha (Segment "Cooking with Martha")
- Jason Allen
- DEA Man Meat #1 (Segment "Cooking with Martha")
- Mark Bowen
- DEA Man Meat #2 (Segment "Cooking with Martha")
- Mark Gaiero
- DEA Man Meat #3 (Segment "Cooking with Martha")
- Samuel Helder
- DEA Man Meat #4 (Segment "Cooking with Martha")
- Andrew Lerch
- DEA Man Meat #5 (Segment "Cooking with Martha")
- Charles Randolph
- DEA Man Meat #6 (Segment "Cooking with Martha")
- Vikrum Shah
- Ajmal (Segment "Fundamentalist Girls Gone Wild")
- Nicholas Wayne Thompson
- Ali (Segment "Fundamentalist Girls Gone Wild")
- Michelle Alexandria
- Burka Woman (Segment "Fundamentalist Girls Gone Wild")
- Maria Petros
- Burka Woman #2 (Segment "Fundamentalist Girls Gone Wild")
- Shelly Skhal
- Burka Woman #3 (Segment "Fundamentalist Girls Gone Wild")
- Beverly Polcyn
- Sweet Granny (Segment "Granny Bust")
- La Monde Byrd
- DEA Agent #1 (Segment "Granny Bust")
- Ingo Neuhaus
- DEA Agent #2 (Segment "Granny Bust")
- Kenneth Kels
- DEA Agent #3 (Segment "Granny Bust")
- Patrick Gough
- DEA Agent #4 (Segment "Granny Bust")
- John Reynolds
- DEA Agent #5 (Segment "Granny Bust")
- Mike Prochaska
- DEA Agent #6 (Segment "Granny Bust")
- Ric Smith
- Meth-Head Itchy (Segment "Granny Bust")
- John Santos
- Meth-Head Scratchy (Segment "Granny Bust")
- James Branaman
- Yuppie Golfer (Segment "Pfot by Phrizer")
- John Hasekian
- Yuppie Accountant (Segment "Pfot by Phrizer")
- Alex Cox
- Yuppie Businessman (Segment "Pfot by Phrizer")
- Lucas Cox
- Yuppie Todd (Segment "Pfot by Phrizer")
- Jamie Ford
- Yuppie Heidi (Segment "Pfot by Phrizer")
- Frank Kramer
- Yuppie Randy (Segment "Pfot by Phrizer")
- Kip Weeks
- Bill (Stoner #1) (Segment "Chillin' on the Couch")
- Alex Rodruquez
- Matt - Stoner #2 (Segment "Chillin' on the Couch")
- Adam Gropman
- Government Spokesman (Segment "Anti-Pot")
- Domenick Dicce
- Nervous Dater (Segment "Anti-Pot")
- Smokey Miles
- Self - Count Smokula (Segment "Anti-Pot")
- Doug Benson
- Self - Comedian
- Mark Cohen
- Self - Comedian
- Dan Gabriel
- Self - Comedian
- Jason Gillearn
- Self - Comedian
- Al Madrigal
- Self - Comedian
- Jackie Martling
- Self - Comedian
- Henry Phillips
- Self - Comedian
- Tom Rhodes
- Self - Comedian
- Jasper Redd
- Self - Comedian
- Rick Overton
- Self - Street Interview
- Ron Shock
- Self - Comedian
- Mike Saccone
- Self - Street Interview
- Stanley Ullman
- Self - Street Interview
- Dana Eagle
- Self - Street Interview
- Karl Bender
- Self - Street Interview
- Jenny Wells
- Self - Street Interview
- Jamie Hogan
- Self - Street Interview
- Alana Sands
- Self - Street Interview
- Kevin Sands
- Self - Street Interview
- Harvey Zane
- Self - Street Interview
- Flip Schultz
- Self - Street Interview
- Jared Shoemaker
- Self - Street Interview
- Franklyn Ajaye
- Self
- Misa Doi
- Bystander
