- Keith David
- Spawn
- Richard Dysart
- Cogliostro
- Michael Nicolosi
- Clown
- Dominique Jennings
- Wanda Blake
- Victor Love
- Terry Fitzgerald / Bobby (voice)
- Kath Soucie
- Cyan / Additional Voices (voice)
- James Keane
- Sam Burke / Tony Twist (voice)
- Michael McShane
- Twitch Williams / Gareb (voice)
- John Rafter Lee
- Jason Wynn
- Ronny Cox
- Senator Scott McMillan / Billy Kincaid (voice)
- Jamie Hanes
- Overkill / Violator (voice) (as James Hanes)
- Ruben Santiago-Hudson
- Jess Chapel
- Denise Poirier
- Angela / Additional Voices (voice)
- Michael Yama
- Cain
- Charlie Adler
- Additional Voices
- Tony Amendola
- Additional Voices
- John DeMita
- Additional Voices
- Alex Fernandez
- Additional Voices
- Matthew Flint
- Additional Voices
- Steve Franken
- Additional Voices
- John Hostetter
- Additional Voices
- Seth Margolis
- Additional Voices
- Vince Melocchi
- Additional Voices
- Matt K. Miller
- Additional Voices
- Andrew Philpot
- Additional Voices
- Paul Raci
- Additional Voices
- Pamela Adlon
- Additional Voices