- Mark Moraghan
- Narrator
- Jamie Campbell Bower
- Skiff (UK & US)
- Nathan Clarke
- Alfie (UK & US)
- Teresa Gallagher
- Emily (UK) / Belle (UK & US) / Annie and Clarabel (UK & US) / Judy (UK & US) / The Female Entertainer (UK & US) / The Children (UK & US) / Passengers (UK & US) (voice)
- Rasmus Hardiker
- Philip (UK & US) / Monty (UK) (voice)
- John Hasler
- Thomas (UK)
- Steven Kynman
- Duck / Ryan / Jack / Mike's Driver (voice)
- Joe Mills
- Oliver (UK & US) / Toad (UK & US) (voice)
- Tracy-Ann Oberman
- Daisy (UK & US)
- Maggie Ollerenshaw
- Henrietta (UK & US)
- Nigel Pilkington
- Percy (UK)
- Rob Rackstraw
- Toby (UK) / Flynn (UK & US) / Mr. Fergus Duncan (UK & US) / The Thin Clergyman (UK & US) (voice)
- Tom Stourton
- Rex (UK & US)
- Tim Whitnall
- Mike (UK & US) / Jerome (UK & US) / Oliver (UK & US) / Max (UK) (voice)
- Keith Wickham
- Edward (UK) / Henry (UK) / Gordon (UK) / James (UK) / Harvey (UK & US) / Whiff (UK) / Bert (UK & US) / Stafford (UK & US) / Sir Topham Hatt (UK & US) / Dowager Hatt (UK & US) / Duck's Driver (UK & US) / Willie (UK & US) / The Wellsworth Stationmaster (UK & US) / The Knapford Station Worker (UK & US) / The Museum Manager (UK & US) / The Policeman (UK & US) / The Male Entertainer (UK & US) / The Quarry Worker (UK & US) / The Bakers (UK & US) / Passengers (UK & US) (voice)
- Matt Wilkinson
- Stanley (UK) / Rocky (UK) / Cranky (UK) / Rex's Driver (UK & US) / Captain Joe (UK & US) (voice)
- David Menkin
- Porter (UK & US)
