- Edward G. Robinson
- Arthur Ferguson Jones / 'Killer' Mannion
- Jean Arthur
- Miss Wilhelmina Clark
- Arthur Hohl
- Detective Sergeant Boyle
- James Donlan
- Detective Sergeant Howe
- Arthur Byron
- Spencer
- Wallace Ford
- Healy
- Donald Meek
- Hoyt
- Etienne Girardot
- Seaver
- Edward Brophy
- 'Slugs' Martin
- Paul Harvey
- 'J.G.' Carpenter
- Harry Abrahams
- Convict
- Ernie Adams
- Reporter
- Carmen Andre
- Clerk
- Chester A. Bachman
- Policeman
- Eddie Baker
- Policeman
- Lucille Ball
- Bank Employee
- H. Barnum
- Undetermined Secondary Role
- George Barton
- Policeman
- Arthur Belasco
- Policeman
- Brooks Benedict
- Reporter
- Joseph E. Bernard
- Policeman
- Stanley Blystone
- Charlie - Clerk
- Harry Bowen
- Mike O'Connor - Taxi Driver
- Ed Brady
- Trustee
- Lynton Brent
- Warden's Secretary
- Maurice Brierre
- Clerk
- Don Brodie
- Reporter
- Vance Carroll
- Policeman
- Monte Carter
- Undetermined Secondary Role
- Nancy Caswell
- Clerk
- Allan Cavan
- Conductor
- Eddy Chandler
- Guard / Driver (uncredited)
- Jack Cheatham
- Guard with Warden
- Ivan Christy
- Customer
- Steve Clark
- Convict
- Nick Copeland
- Waiter
- Jules Cowles
- Convict
- Kernan Cripps
- Policeman / Guard (uncredited)
- Floyd Criswell
- Motorcycle Officer
- Charles Cross
- Reporter
- Sidney D'Albrook
- Waiter
- Bobbie Dale
- Cameraman
- Edwards Davis
- Captain, S.S. Shanghai
- Lew Davis
- Ship Steward
- Sidney De Gray
- Customer
- Gordon De Main
- Undetermined Secondary Role
- Rita Donlin
- Undetermined Secondary Role
- Allyn Drake
- Telephone Operator
- Lowell Drew
- (uncredited)
- Harry Dunkinson
- Customer
- Jay Eaton
- Undetermined Secondary Role
- Pearl Eaton
- Undetermined Secondary Role
- Effie Ellsler
- Aunt Agatha
- Eddie Fetherston
- Cameraman
- Budd Fine
- Policeman
- Larry Fisher
- Trustee
- Sam Flint
- City Commissioner
- Bess Flowers
- Miss Gower - Secretary
- Francis Ford
- Newspaper Reporter at Dock
- May Foster
- Fat Woman
- Rosita Foucher
- Telephone Operator
- Christian J. Frank
- Undetermined Secondary Role
- George Frank
- Customer
- Desmond Gallagher
- Policeman
- Robert Graves
- Undetermined Secondary Role
- Maurine Gray
- Undetermined Secondary Role
- Roger Gray
- Customer
- Jack Grey
- Policeman
- Carlton Griffin
- Undetermined Secondary Role
- Kit Guard
- Convict
- Sherry Hall
- Reporter
- Eddie Hart
- Gangster
- Pat Hartigan
- Policeman
- Bernadene Hayes
- Waitress
- Grace Hayle
- Reporter
- Edward Hearn
- Policeman Announcing Carpenter
- Oscar 'Dutch' Hendrian
- Gangster
- Charles H. Hickman
- Detective
- Pauline High
- Undetermined Secondary Role
- Rodney Hildebrand
- Policeman
- Al Hill
- One of Mannion's Henchmen
- Carol Holloway
- Customer
- Robert Homans
- Detective
- Arthur Stuart Hull
- City Official
- John Ince
- Undetermined Secondary Role
- Mitchell Ingraham
- Undetermined Secondary Role
- Sunny Ingraham
- Secretary
- John Irwin
- Convict
- Gladden James
- Secretary
- Bud Jamison
- Policeman
- William Jeffrey
- Bank Manager
- Ed Jones
- Undetermined Secondary Role
- Edward Keane
- U.S. Deputy Attorney
- Cornelius Keefe
- Radio Man
- Charles King
- Cameraman
- Brady Kline
- Policeman
- Ethan Laidlaw
- Police Switchboard Operator
- Jerry Larkin
- Porter
- W.E. Lawrence
- Customer
- Peggy Leon
- Undetermined Secondary Role
- Tom London
- Guard
- Walter Long
- Convict
- J. Farrell MacDonald
- Prison Warden
- Stanley Mack
- Gangster
- Frank Marlowe
- Ship Steward
- Charles Marsh
- Undetermined Secondary Role
- Charles McAvoy
- Policeman
- Charles McMurphy
- Policeman
- Philip Morris
- Detective
- Harry Mount
- Newsboy
- Jack Mower
- Guard
- Ferdinand Munier
- Mayor
- Irving Newhoff
- Henchman
- Ned Norton
- Reporter
- Frank O'Connor
- Detective Removing Handcuffs
- Robert Emmett O'Connor
- Police Lt. Mack
- Pat O'Malley
- Detective
- Ted Oliver
- Motorcycle Officer
- Robert Parrish
- Undetermined Secondary Role
- Steve Pendleton
- Convict
- Jimmy Phillips
- Pickpocket
- Virginia Pine
- Seaver's Secretary
- Richard Powell
- Police Lieutenant in Bank
- Hal Price
- Fingerprint Expert
- James Quinn
- Pickpocket
- Arthur Rankin
- Clerk
- Ralph Remley
- Sam Dixon - Office Ribber
- Jack Richardson
- Detective
- Don Roberts
- Undetermined Secondary Role
- Ky Robinson
- Detective
- Oscar Rudolph
- Office Clerk Bringing Telegram
- Dick Rush
- Policeman
- Jack Santoro
- Reporter
- William Saverick
- Cameraman
- Joe Sawyer
- Nick - Mannion's Henchman
- Allan Sears
- Policeman
- Harry Semels
- Italian Visitor
- Marion Sheldon
- Undetermined Secondary Role
- Frank Sheridan
- Russell - Prison Official
- Charles Sherlock
- Reporter
- Lee Shumway
- Police Sergeant
- Reginald Simpson
- Undetermined Secondary Role
- Phillips Smalley
- City Official
- Robert Stanley
- Reporter
- Larry Steers
- Undetermined Secondary Role
- Charles Sullivan
- Henchman
- Ben Taggart
- Traffic Officer
- Harry Tenbrook
- Mannion's Henchman on Lookout
- Arthur Thalasso
- Gatekeeper
- William L. Thorne
- Policeman
- John Tyke
- Convict
- Charles Unger
- Undetermined Secondary Role
- Emmett Vogan
- Reporter
- Terry Walker
- Undetermined Secondary Role
- Blue Washington
- Bank Doorman
- Billy West
- Elevator Man
- Lloyd Whitlock
- Undetermined Secondary Role
- Robert Wilber
- Henchman
- Corinne Williams
- Undetermined Secondary Role
- Maston Williams
- Convict
- William A. Williams
- Undetermined Secondary Role
- Clarence Wilson
- Head of Chamber of Commerce
- Harry Wilson
- Convict
- John Wray
- Henchman Harry
- Ernie Young
- Undetermined Secondary Role
