- James Stewart
- Charles Augustus 'Slim' Lindbergh
- Murray Hamilton
- Bud Gurney
- Patricia Smith
- Mirror Girl
- Bartlett Robinson
- Benjamin Frank Mahoney - President, Ryan Airlines Co.
- Marc Connelly
- Father Hussman
- Arthur Space
- Donald Hall - Chief Engineer, Ryan Airlines
- Charles Watts
- O.W. Schultz - Salesman, Atlas Suspender Co.
- Erville Alderson
- Burt
- Frances Allen
- Mother from Oklahoma
- David Alpert
- Clerk
- Don Ames
- Crowd Member in France
- Walter Bacon
- Crowd Member in France
- Gordon Barnes
- Reporter
- Griff Barnett
- Dad - Farmer
- Jimmy Bates
- Farm Boy
- Brandon Beach
- Train Passenger
- Paul Birch
- Blythe
- Eumenio Blanco
- Crowd Member in France
- Sheila Bond
- Model / Dancer (uncredited)
- Eugene Borden
- French Gendarme
- Chet Brandenburg
- Crowd Member in France
- Paul Brinegar
- Okie
- George Bruggeman
- Train Passenger
- Robert Burton
- Maj. Albert Lambert - Lindbergh Sponsor
- John Carlyle
- Bridegroom
- Noble 'Kid' Chissell
- Passerby at Train Station
- Virginia Christine
- Secretary
- Rena Clark
- Bride
- Robert Cornthwaite
- Harry Knight - Lindbergh Student
- Jack Daly
- Louie
- Richard Deacon
- Charles Levine - President, Columbia Aircraft Co.
- Pauline Drake
- Sob Sister
- Duke Fishman
- Aircraft Mechanic
- Slim Gaut
- Aircraft Mechanic
- Roy Gordon
- Associate Producer
- Dabbs Greer
- Goldsborough
- Kit Guard
- Crowd Member in France
- Creighton Hale
- Man Driving Car
- Olin Howland
- Surplus Dealer
- J. Anthony Hughes
- Reporter
- Dick Johnstone
- Aircraft Mechanic
- Walter Kingson
- Newscaster
- Richard LaMarr
- Crowd Member in France
- Norman Leavitt
- Ryan Aircraft Employee
- Johnny Lee
- Jess - Cook at Louie's Shack
- Nelson Leigh
- Director
- Herbert Lytton
- Casey Jones
- James Macklin
- Reporter
- Maurice Manson
- E. Lansing Ray - Editor, St. Louis Globe Democrat
- David Orrick McDearmon
- Harold Bixby - St. Louis Chamber of Commerce
- John McKee
- Reporter
- David McMahon
- Lane
- William Meader
- Reporter
- Russell Meeker
- Train Passenger
- Gordon Mitchell
- (uncredited)
- Ann Morrison
- Mrs. Fearless
- George Nardelli
- Crowd Member in France
- Stuart Nedd
- Reporter
- Bill Neff
- Cadet
- James O'Rear
- Earl Thompson
- Alan Paige
- Reporter
- Jack Perrin
- Passerby at Train Station
- Lee Roberts
- Photographer
- James Robertson Jr.
- Bill Robertson
- Robert Robinson
- Passerby at Train Station
- Syd Saylor
- Photographer
- Scott Seaton
- Passerby at Train Station
- George Selk
- Mechanic
- Bernard Sell
- Aircraft Mechanic
- Cap Somers
- Crowd Member in France
- Aaron Spelling
- Mr. Fearless
- Brick Sullivan
- Passerby at Train Station
- Ernie Taylor
- Sailor
- Percival Vivian
- Professor
- Max Wagner
- Reporter
- Ray Walker
- Barker
- Harlan Warde
- Boedecker
- Will J. White
- Cadet
- Robert B. Williams
- Editor - San Diego
- Rush Williams
- Reporter
- Carleton Young
- Captain at Brooks Field Flight School
- Chief Yowlachie
- Indian
