- Elisabeth Sladen
- Â Sarah Jane Smith 54 episodes, 2007-2011
- Daniel Anthony
- Â Clyde Langer / ... 53 episodes, 2007-2011
- Alexander Armstrong
- Â Mr Smith 48 episodes, 2007-2011
- Tommy Knight
- Â Luke Smith / ... 44 episodes, 2007-2011
- Anjli Mohindra
- Â Rani Chandra 41 episodes, 2008-2011
- Ace Bhatti
- Â Haresh Chandra 24 episodes, 2008-2011
- Mina Anwar
- Â Gita Chandra 18 episodes, 2008-2011
- Paul Kasey
- Â Blakeman / ... 18 episodes, 2007-2011
- Yasmin Paige
- Â Maria Jackson 15 episodes, 2007-2010
- Joseph Millson
- Â Alan Jackson 12 episodes, 2007-2008
- John Leeson
- Â Voice of K9 / ... 12 episodes, 2007-2010
- Jimmy Vee
- Â The Graske / ... 12 episodes, 2007-2010
- Juliet Cowan
- Â Chrissie Jackson 11 episodes, 2007-2008
- Ruari Mears
- Â Heidi Slitheen / ... 8 episodes, 2007-2010
- Jocelyn Jee Esien
- Â Carla Langer 6 episodes, 2008-2011
- Sinead Michael
- Â Sky 6 episodes, 2011
- Paul Marc Davis
- Â The Trickster 6 episodes, 2007-2009
- Philip Hurd-Wood
- Â Voice of The Graske / ... 6 episodes, 2007-2010
- Floella Benjamin
- Â Professor Rivers 5 episodes, 2007-2011
- Tom Read James
- Â Kevin 1 episode, 2009-2011
- Pamela Merrick
- Â Wendy 4 episodes, 2007
- Mark Goldthorp
- Â Androvax 4 episodes, 2009-2010
- Anthony O'Donnell
- Â Kaagh 4 episodes, 2008-2009
- Jason Mohammad
- Â Newsreader 4 episodes, 2007-2011
- Jon Glover
- Â Additional Shansheeth Voices / ... 3 episodes, 2010
- Samantha Bond
- Â Mrs Wormwood 3 episodes, 2007-2008
- Elijah Baker
- Â Steve Wallace 3 episodes, 2008-2011
- Cyril Nri
- Â The Shopkeeper / ... 2 episodes, 2010-2011
- Matt Smith
- Â The Doctor 2 episodes, 2010
- Bradley Walsh
- Â Elijah Spellman / ... 2 episodes, 2008-2009
- Russ Abbot
- Â Martin Trueman 2 episodes, 2008
- Carryl Thomas
- Â Cheryl Farley 2 episodes, 2008
- David Tennant
- Â The Doctor 2 episodes, 2008-2010
- Suranne Jones
- Â Mona Lisa 2 episodes, 2009
- Donald Sumpter
- Â Erasmus Darkening 2 episodes, 2009
- Julian Bleach
- Â The Nightmare Man 2 episodes, 2010
- Amber Beattie
- Â Queen Jane 2 episodes, 2010
- Joplin Sibtain
- Â Mark Grantham 2 episodes, 2007
- Callum Blue
- Â Lord Marchwood 2 episodes, 2009
- Nigel Havers
- Â Peter Dalton 2 episodes, 2009-2010
- Souad Faress
- Â Old Rani 2 episodes, 2009
- Angus Wright
- Â Mister Dread 2 episodes, 2010
- Elizabeth Rider
- Â Mistress Ellen 2 episodes, 2010
- Sarah Haynes
- Â Carrie Metcalf 2 episodes, 2007
- Miriam Margolyes
- Â Leaf Blathereen 2 episodes, 2009
- Gregg Sulkin
- Â Adam 2 episodes, 2009
- Adam Gillen
- Â Toby Silverman 2 episodes, 2009
- Terence Maynard
- Â Madison Yorke 2 episodes, 2009
- Jeff Rawle
- Â Mr Harding 2 episodes, 2009
- Katy Manning
- Â Jo Jones 2 episodes, 2010
- Fiona Hampton
- Â Lady Matilda 2 episodes, 2010
- Joe Mason
- Â Gavin 2 episodes, 2010
- James Dreyfus
- Â Harrison 2 episodes, 2011
- Lily Loveless
- Â Ellie 2 episodes, 2011
- Rosanna Lavelle
- Â Barbara Smith 2 episodes, 2008-2009
- Jane Asher
- Â Andrea 2 episodes, 2007
- Phyllida Law
- Â Bea Nelson-Stanley 2 episodes, 2007
- Jay Simpson
- Â Jay 2 episodes, 2007
- Martyn Ellis
- Â Blakeman 2 episodes, 2007
- Ronan Vibert
- Â Professor Nicholas Skinner 2 episodes, 2008
- Simon Callow
- Â Voice of Tree Blathereen 2 episodes, 2009
- Amelia Clarkson
- Â Elizabeth Marchwood 2 episodes, 2009
- Brian Miller
- Â Harry 2 episodes, 2009
- Robert Curtis
- Â Security Man 2 episodes, 2009
- Julie Graham
- Â Ruby White 2 episodes, 2010
- Finn Jones
- Â Santiago Jones 2 episodes, 2010
- Cheryl Campbell
- Â Ocean Waters 2 episodes, 2010
- Richard Wisker
- Â George 2 episodes, 2010
- Christine Stephen-Daly
- Â Miss Myers 2 episodes, 2011
- Mark Aiken
- Â Serf 2 episodes, 2011
- Christopher Pizzey
- Â Eddie Smith 2 episodes, 2008-2009
- Liza Sadovy
- Â Miss Trupp 2 episodes, 2009
- Sarah Crowden
- Â Mrs Gribbins 2 episodes, 2007
- Ian Midlane
- Â Jeffrey 2 episodes, 2007
- Sonny Muslim
- Â Lance 2 episodes, 2007
- Holly Atkins
- Â Heidi 2 episodes, 2007
- Gary Beadle
- Â Paul Langer 2 episodes, 2008-2009
- Clare Thomas
- Â Lucy Skinner 2 episodes, 2008
- Nicholas Courtney
- Â Sir Alistair Lethbridge-Stewart 2 episodes, 2008-2010
- Toby Parkes
- Â Sam 2 episodes, 2009
- Rhys Gear
- Â Joseph Marchwood 2 episodes, 2009
- Eddie Marsan
- Â Mr. White 2 episodes, 2010
- Tom Wlaschiha
- Â Koenig 2 episodes, 2010
- Laila Rouass
- Â Colonel Karim 2 episodes, 2010
- David Webber
- Â Minty 2 episodes, 2010
- Edyta Budnik
- Â Adriana 2 episodes, 2011
- Gavin Brocker
- Â Caleb 2 episodes, 2011
- Sara Houghton
- Â Doctor Madigan 2 episodes, 2011
- Huw Higginson
- Â Mr Cunningham 2 episodes, 2008
- Doreen Mantle
- Â Mrs Randall 2 episodes, 2007
- Ryan Watson
- Â Nathan Goss 2 episodes, 2007
- James Bellamy
- Â Brandon Butler 2 episodes, 2007
- Eleanor Tomlinson
- Â Eve 2 episodes, 2009
- Peter Bowles
- Â Lionel Carson 2 episodes, 2011
- Gwyneth Keyworth
- Â Emily 2 episodes, 2010
- Beth Goddard
- Â Sister Helena 2 episodes, 2007-2009
- Imogen Bain
- Â Janine 2 episodes, 2007-2010
- Jessica Ashworth
- Â Young Sarah Jane 2 episodes, 2007-2009
- Nadiyah Davis
- Â Jen 2 episodes, 2007
- Simon Chadwick
- Â Major Cal Kilburne 2 episodes, 2008
- Kate Fleetwood
- Â Ship 2 episodes, 2009
- Nicholas Briggs
- Â Voice of Captain Tybo 2 episodes, 2009
- Dan Starkey
- Â Plark 2 episodes, 2011
- Chloe Savage
- Â Baby Sky 2 episodes, 2011
- Georgie Glen
- Â Mrs King 2 episodes, 2008
- Francesca Miller
- Â Young Andrea 2 episodes, 2007
- Audrey Ardington
- Â The Abbess 2 episodes, 2007-2009
- Anton Thompson McCormick
- Â Carl 2 episodes, 2007
- Ed Hughes
- Â Stuart Farley 2 episodes, 2008
- Zienia Merton
- Â Registrar 2 episodes, 2009-2010
- Lucie Jones
- Â Gemma 2 episodes, 2010
- Ella Savage
- Â Baby Sky 2 episodes, 2011
- Christine Furness
- Â Cashier 2 episodes, 2007
- Rob Madge
- Â Oscar 2 episodes, 2008
- Sarah Paul
- Â Miss Jerome 2 episodes, 2009
- Morgan-Faith Hughes
- Â Katy 2 episodes, 2010
- Ben Ashley
- Â Shansheeth 2 episodes, 2010
- Amber Donaldson
- Â Baby Sky 2 episodes, 2011
- Lachele Carl
- Â American Newsreader / ... 2 episodes, 2007-2008
- Silas Carson
- Â Emperor / ... 2 episodes, 2007
- David Bradley
- Â Voice of Shansheeth Blue 2 episodes, 2010
- Llewcus Oaten
- Â Ben 2 episodes, 2010
- Scarlet Donaldson
- Â Baby Sky 2 episodes, 2011
- Christina Greatrex
- Â Voice of Mistress 2 episodes, 2007
- Will Macleod
- Â Voice of The Metalkind 2 episodes, 2011
- Anwar Lynch
- Â Security Guard 1 episode, 2011
- Jem Brownlee
- Â Dave Finn 1 episode, 2008
- Aaron Shosanya
- Â Tony Warner 1 episode, 2008
- Porsha Lawrence-Mavour
- Â Kelsey 1 episode, 2007
- Jamie Davis
- Â Davey 1 episode, 2007
- Doon Mackichan
- Â Louise Marlowe 1 episode, 2010
- Ronnie Corbett
- Â Ambassador Rahnius 1 episode, 2009
- Rungano Nyoni
- Â Secretary 1 episode, 2007
- Perry Millward
- Â Jacob 1 episode, 2008
- Toby Longworth
- Â Voice of the Slitheen 1 episode, 2010
- Perry Blanks
- Â Van Driver 1 episode, 2010
- Philip North
- Â Technician 1 episode, 2007
- Nicky Ladanowski
- Â Lisa Trotter 1 episode, 2008
- Joanna Bending
- Â Linda 1 episode, 2008
- Jessica Mogridge
- Â Young Sarah Jane 1 episode, 2008
- Tony Boncza
- Â Mr Scriven 1 episode, 2009
- Lizo Mzimba
- Â Lizo Mzimba 1 episode, 2009
- Catherine Bailey
- Â Miss Wyckham 1 episode, 2010
- Angela Pleasence
- Â Mystic Mags 1 episode, 2011
- Prasanna Puwanarajah
- Â Car Salesman 1 episode, 2008
- Nicholas Osmond
- Â George 1 episode, 2008
- Calvin Dean
- Â Chris 1 episode, 2009
- Sophie Benjamin
- Â Gill 1 episode, 2010
- Ewart James Jones
- Â Max 1 episode, 2011
- Julian Dutton
- Â Chief Inspector 1 episode, 2007
- Sagar Arya
- Â British Newsreader 1 episode, 2008
- Jessica Lewis
- Â Detention Girl 1 episode, 2008
- Nick Edison
- Â Reporter 1 episode, 2009
- Rowena Cooper
- Â Angela 1 episode, 2010
- Sydney White
- Â Bubbleshock Girl 1 episode, 2007
- Alan Ruscoe
- Â Clown 1 episode, 2008
- Andrew Phillips
- Â Detention Boy 1 episode, 2008
- Anthony Debaeck
- Â French Newsreader 1 episode, 2008
- Edward Judge
- Â Dave 1 episode, 2009
- Scarlett Murphy
- Â Julie 1 episode, 2009
- Jai Rajani
- Â Suresh 1 episode, 2009
- Olivia Hill
- Â TV Reporter 1 episode, 2007
- Andrew Bullivant
- Â PC Ferguson 1 episode, 2008
- Sean Palmer
- Â Clown 1 episode, 2008
- Konnie Huq
- Â Konnie Huq 1 episode, 2007
- Gethin Jones
- Â Gethin Jones 1 episode, 2007
- Peter-Hugo Daly
- Â Hector 1 episode, 2011
- Jon Davey
- Â Shansheeth / ... (uncredited) 3 episodes, 2010
- Cheryl Rowlands
- Â Nun (uncredited) 2 episodes, 2007
- Richard Price
- Â Passerby (uncredited) 2 episodes, 2008
- John R. Walker
- Â Teacher (uncredited) 2 episodes, 2008
- Kristian Arthur
- Â Man in Black (uncredited) 2 episodes, 2010
- Martin Locks
- Â Nick Ali (uncredited) 2 episodes, 2011
- Samantha E. Hunt
- Â Agatha (uncredited) 1 episode, 2007
- Barrie Wharmby
- Â Man with Bubble Shock (uncredited) 1 episode, 2007
- Helen Hughes
- Â Nurse (uncredited) 1 episode, 2007
- Paul Robert Bird
- Â Alien / ... (uncredited) 1 episode, 2008
- Simon Blood DeVay
- Â Security Guard (uncredited) 1 episode, 2011