- Richard Burton
- Marcellus Gallio
- Jean Simmons
- Diana
- Victor Mature
- Demetrius
- Michael Rennie
- Peter
- Jay Robinson
- Caligula
- Dean Jagger
- Justus
- Torin Thatcher
- Sen. Gallio
- Richard Boone
- Pontius Pilate
- Betta St. John
- Miriam
- Jeff Morrow
- Paulus
- Ernest Thesiger
- Emperor Tiberius
- Dawn Addams
- Junia
- Leon Askin
- Abidor
- Michael Ansara
- Judas
- Jan Arvan
- Slave Dealer
- Ben Astar
- Cleander
- Walter Bacon
- Citizen
- John Barton
- Citizen
- Harry Baum
- Minor Role
- Herman Belmonte
- Citizen
- Helen Beverley
- Rebecca
- Eumenio Blanco
- Citizen
- Oscar Blank
- Citizen
- Lulu Mae Bohrman
- Citizen
- Morgan Brown
- Citizen
- Naaman Brown
- Minor Role
- Kit Carson
- Soldier
- Albert Cavens
- Sword-Fighting Soldier
- Fred Cavens
- Sword-Fighting Soldier
- Dick Cherney
- Citizen
- Bud Cokes
- Soldier
- Tom Coleman
- Citizen
- Jean Corbett
- Slave Girl (twin)
- Joan Corbett
- Slave Girl (twin)
- Noreen Corcoran
- Girl
- Sally Corner
- Cornelia
- Jane Crowley
- Minor Role
- Leo Curley
- Shalum
- Roy Damron
- Soldier
- Frank DeKova
- Slave Dealer
- Irene Demetrion
- (uncredited)
- Van Des Autels
- Chamberlain
- John Doucette
- Ship's Mate
- Anthony Eustrel
- Sarpedo
- Dan Ferniel
- Black Man
- Bess Flowers
- Bystander at trial
- Charles Fogel
- Citizen
- John George
- Citizen
- Kenneth Gibson
- Citizen
- Sam Gilman
- Ship's Captain
- Roy Gordon
- Chamberlain
- Michael Granger
- Slave Dealer
- Robert Haines
- Citizen
- Percy Helton
- Caleb - Wine Merchant
- Thomas Browne Henry
- Marius - Physician
- Jimmie Horan
- Citizen
- Shep Houghton
- Soldier
- George Huggins
- Citizen
- Rosalind Ivan
- Julia
- Roy Jenson
- Soldier
- Richard Kean
- Slave Dealer
- Jack Kenny
- Citizen
- George Keymas
- Slave
- Donald C. Klune
- Jesus Christ
- Nicolas Koster
- Jonathan
- Anne Kunde
- Citizen
- Virginia Lee
- Specialty Dancer
- David Leonard
- Marcipor
- Alfred Linder
- Slave Dealer
- Emmett Lynn
- Nathan
- Christey Marlo
- Slave Girl
- Mae Marsh
- Jerusalem Woman Aiding Demetrius
- Merrill McCormick
- Citizen
- George Melford
- (uncredited)
- Frank Mills
- Slave
- Cameron Mitchell
- Jesus Christ
- Eleanor Moore
- (uncredited)
- Ralph Moratz
- Nobleman in Market
- Edward Mundy
- Peddler
- Anton Northpole
- Citizen
- Barry Norton
- Citizen
- Jay Novello
- Tiro
- Arthur Page
- Reuben
- Francis Pierlot
- Dodinius
- 'Snub' Pollard
- Citizen
- Alex Pope
- Roman Officer
- Guy Prescott
- Quintus - Tribune
- Ford Rainey
- Ship's Captain
- Ford Raymond
- Citizen
- Peter Raynolds
- Lucius
- Anthony Redondo
- Roman Soldier
- John Rice
- Soldier
- Pamela Robinson
- Lucia
- George Robotham
- Slave with Demetrius at Palm Procession
- Hayden Rorke
- Caluus - Slave Auction Bidder
- Danny Sands
- Soldier
- Gloria Saunders
- Slave Girl
- Norbert Schiller
- Slave Dealer
- Harry Shearer
- David
- Mabel Smaney
- Citizen
- Marc Snegoff
- (uncredited)
- Marc Snow
- Auctioneer
- Bert Spencer
- Citizen
- Paul Stathes
- Citizen
- Murray Steckler
- Melas
- George E. Stone
- Gracchus
- Arthur Tovey
- Roman Soldier
- Ellinor Vanderveer
- Citizen
- Eleanore Vogel
- Minor Role
- Otto Waldis
- Slave Dealer
- Gene Wesson
- Soldier
- Sally Yarnell
- Citizen
