- John Dallimore
- Vicar
- James D'Arcy
- Nicholas Nickleby
- Sophia Myles
- Kate Nickleby
- Diana Kent
- Mrs. Nickleby
- Charles Dance
- Ralph Nickleby
- George Innes
- Newman Noggs
- Abigail McKern
- Miss La Creevy
- Gregor Fisher
- Mr. Squeers
- Archie Preston
- Small Boy
- Berwick Kaler
- Mr. Snawley
- Lee Ingleby
- Smike
- Pam Ferris
- Mrs. Squeers
- Chris Roebuck
- Wackford Squeers Jnr.
- Debbie Chazen
- Fanny Squeers
- Tom Hollander
- Mr. Mantalini
- Marian McLoughlin
- Madame Mantalini
- Hannah Storey
- Tilda Price
- Rosalind March
- Miss Knag
- Lorraine Stanley
- Maid
- Tom Ellis
- John Browdie
- Lucy Bowen
- Cockney Girl
- Tim Barlow
- Old Lord
- Donald Sumpter
- Mr. Brooker
- Philip Croskin
- Bailiff
- Charles Cork
- Bailiff
- Alex Knight
- Landlord
- Malcolm Tierney
- Vincent Crummles
- Jacqueline Tong
- Mrs. Crummles
- Ruth Chapman
- The Infant Phenomenon
- Richard Katz
- Mr. Lenville
- Kitty Leigh
- Miss Ledrock
- Roderic Culver
- Lord Verisopht
- Dominic West
- Sir Mulberry Hawk
- Helena Leonard
- Opera Singer
- Emma Gregory
- Miss Bravassa
- John Hopkins
- Lord
- Tom Hiddleston
- Lord
- Danny Babington
- Agency Clerk
- Jonathan Coy
- Charles Cheeryble
- JJ Feild
- Frank Cheeryble
- Simeon Andrews
- Ned Cheeryble
- Katherine Holme
- Madeleine Bray
- Philip Bond
- Walter Bray
- Liz Smith
- Peg Sliderskew
- Frank Mills
- Arthur Gride
- Peter Gale
- Doctor
- Bindu De Stoppani
- (uncredited)
- Allin Kempthorne
- Lord
- João Costa Menezes
- Begger
