- Ingrid Bergman
- Gladys Aylward
- Curd Jürgens
- Capt. Lin Nan
- Robert Donat
- The Mandarin of Yang Cheng
- Michael David
- Hok-A
- Athene Seyler
- Jeannie Lawson
- Ronald Squire
- Sir Francis Jamison
- Moultrie Kelsall
- Dr. Robinson
- Richard Wattis
- Mr. Murfin
- Peter Chong
- Yang
- Tsai Chin
- Sui-Lan
- Edith Sharpe
- Secretary at China Inland Mission
- Joan Young
- Sir Francis' Cook
- Lian-Shin Yang
- Woman with Baby
- Noel Hood
- Miss Thompson
- Burt Kwouk
- Li
- Chris Adcock
- Russian Soldier
- Frank Blaine
- Madman
- Alexis Bobrinskoy
- Russian Fireman
- Edwina Carroll
- Chinese Dancer
- Christopher Chen
- Tax Collector
- Lin Chen
- Innkeeper's Wife
- David Goh
- Japanese Lieutenant
- Frank Goh
- Timothy
- Ursula Granville
- Missionary
- George Holdcroft
- Train Passenger
- Ronald Kyaing
- Young Lin
- Judith Lai
- Sixpence
- Ronald Lee
- Chief Muleteer
- Aileen Lewis
- Train Passenger
- Louise Lin
- Mai Da
- Jack Mandeville
- Train Passenger
- Alf Mangan
- Train Passenger
- Richard Marner
- Russian Soldier
- André Mikhelson
- Russian Commissar
- Stanislaw Mikula
- Russian Conductor
- Aung Min
- Buddhist Priest
- Mitch Mitchell
- Bit Part
- Philip Needs
- Little boy on train,
- Reg Thomason
- Train Passenger
- Myo Toon
- Chinese Soldier / Mountain Bandit / Prison Guard (uncredited)
- Michael Wee
- Mandarin's Aide
- Vincent Wong
- Chinese Captain
- Woffles Wu
- Orphan Boy
- Ye-Min
- Bai-Bao
- Ric Young
- Bit part
- Zed Zakari
- Chief Prison Guard Reporting Riot
- Stanley Zevic
- Russian Officer
