- John Wayne
- Larry Baker
- Shirley Grey
- Gloria Martin / Gloria Stratton (as Shirley Gray)
- Conway Tearle
- Stevens
- Tully Marshall
- Howard Edwards
- Edmund Breese
- Frank Stratton
- Lloyd Whitlock
- Walter Gray
- Al Bridge
- Carlson
- Matthew Betz
- Tom Jordan
- Joseph W. Girard
- Detective Matthews
- James P. Burtis
- Detective Hemmingway
- Ernie Adams
- Barney
- Charles King
- Mike
- J. Farrell MacDonald
- Jim Baker
- Al Ferguson
- Sandy
- Glenn Strange
- Jim
- Victor Adamson
- Baggage Master / Farmer / Train Passenger / Bob (uncredited)
- Yakima Canutt
- Henchman
- Henry Hall
- Doctor
- Rodney Hildebrand
- Bill
- Eddie Parker
- Co-Pilot / Det. Nick / Doctor (uncredited)
- Fred Parker
- Plane Passenger
- Fred 'Snowflake' Toones
- Sam
