- Sandra Bullock
- Ashburn
- Melissa McCarthy
- Mullins
- Demián Bichir
- Hale
- Marlon Wayans
- Levy
- Michael Rapaport
- Jason Mullins
- Jane Curtin
- Mrs. Mullins
- Spoken Reasons
- Rojas
- Dan Bakkedahl
- Craig
- Taran Killam
- Adam
- Michael McDonald
- Julian
- Tom Wilson
- Captain Woods
- Peter Weireter
- SWAT Team Leader
- John Ross Bowie
- NY Agent
- William Xifaras
- Tough Guy #1
- Cary 'Big Shug' Guy
- Tough Guy #2
- Erica Derrickson
- Prostitute
- Tony Hale
- The John
- Deirdre Horgan
- Police Dispatch
- William Ambrose Kennedy
- Desk Sergeant
- Tony V.
- Precinct Officer
- Amanda Good Hennessey
- Woman with Kid
- Patty Ross
- Drunk Woman
- Kaitlin Olson
- Tatiana
- Ellen Becker-Gray
- Tatiana's Mother
- Andy Buckley
- Robin
- Don Orsillo
- Baseball Announcer
- Adam Ray
- LeSoire
- Chris Gethard
- Chris Gethard
- Dane Anton Aska III
- Club Ekko Bartender
- Joey McIntyre
- Peter Mullins
- Michael Tucci
- Mr. Mullins
- Bill Burr
- Mark Mullins
- Nate Corddry
- Michael Mullins
- Jessica Chaffin
- Gina / Gina's Boobs (as Jessica Chaffin's Boobs)
- Jamie Denbo
- Beth
- Miriam Tolan
- Pathologist
- Alexis Garcia
- Drug Dealer in Paint Factory
- Raw Leiba
- Paint Factory Henchman
- Ben Falcone
- Blue Collar Man
- Joe Stapleton
- O'Flanagan's Mother
- Steve Bannos
- Wayne
- Fletcher McTaggart
- Choking Man
- Zach Woods
- Paramedic
- Joe Garland
- Boston Agent
- Thomas B. Devlin
- Boston Agent
- Benjamin Evett
- Boston Agent
- Elliot Santiago
- Dealer
- Mitch Silpa
- Dealer
- Katie Dippold
- ER Nurse
- Kelby Turner Akin
- Orderly
- Lance Norris
- Scruffy Bar Patron
- Michelle Turner Young
- LeSoire Dancer
- Tyler Clark
- LeSoire Dancer
- Devon Diep
- LeSoire Dancer
- Anna Lapteva
- LeSoire Dancer
- Lee
- Police Dog
- Ralph
- Police Dog
- Skylar
- Pumpkin the Cat
- Tylar
- Pumpkin the Cat
- Samantha
- Mullins' Dog
- Luing Andrews
- Officier Blake
- Ahmaad Aspen
- Cameo
- Lilith Astaroth
- Nightclub Attendee
- Don L. Bagley
- Bar Patron (Donnie)
- Danny Belford
- Dancer
- Marshall Berenson
- Special Agent Duncan
- William Bloomfield
- FBI Agent
- Brina
- Business Woman
- Rick Burtt
- FBI Agent
- Chemi Che-Mponda
- Pedestrian
- Talli Clemons
- Inmate
- Guy Cooper
- Police Officer
- Christopher Coulouras
- Driver / Man on Street (uncredited)
- Grace Curley
- Cruise Boat Patron
- Luis Da Silva Jr.
- Dealer#4
- Aaron Dorsey
- Orderly
- Steven Dougherty
- Dealer #5
- Frank Durant
- Prisoner
- Michele Egerton
- Prisoner Inmate's Wife
- Paul Feig
- Doctor
- John Franchi
- Bar Patron
- Dave Gabanelli
- Factory Worker
- Flora Genet
- Bar Patron
- Mickey Gilmore
- Inmate
- Maria Green
- Pedestrian
- Brett Gustafson
- Club Goer
- London Hall
- Denny's patron,precesion driver
- Mark Hawk
- Police Officer
- Conor Healy
- Messenger
- Paul Held
- Businessman
- Lin Hult
- Club Patron
- Frankie Imbergamo
- Hospital Visitor
- Liz Imperio
- Fainting Barmaid
- Charles Matumbi Jackson
- Bar Patron
- Emma Jonnz
- Emma
- Ken Kansky
- Club Ekko Bouncer
- Colleen Kelly
- Detective
- John Joseph Lindsey
- Detective at PD Station
- Frantz Louizia
- Club Motivator
- Charles Luise
- FBI SWAT
- Paul Lussier
- FBI Security Officer
- Phyllis Lynn
- Park Pedestrian
- Gwen MacKay
- Denny's Patron
- Tatyanna Malagutti
- Club Girl
- Conan Marchi
- FBI Agent
- Tom Mariano
- Boston Police Officer
- Doreen Marshall
- Pedestrian
- Daniel Martignetti
- Police Videographer
- Robert Masiello
- Hospital Patient
- Jamie Mazareas
- Bar Patron
- Michael McCarthy
- Club Patron
- James McDonough
- Pedestrian
- Sean McFarlane
- Police Officer
- Madeleine McKenzie
- Club Waitress
- Sean McPherson
- Police Officer
- Keith Middlebrook
- Officer Russo
- Christopher Mikael
- Drunk Poker Player
- Vanessa Morrison
- Federal Agent
- Ken Murray
- Warehouse Worker
- Alexandra Murrietta
- Club-Goer
- Angelina Natale
- Daughter
- Cassidy Neal
- Party Boat Patron
- Leigh Nicole
- Club Patron
- A.J. O'Connell
- FBI Agent
- Ryan O'Connor
- Onlooker
- Ed O'Keefe
- Dart Player
- Joseph Oliveira
- Angel
- Richard Pacheco
- Man in Car
- Christel Poirier
- Prostitute
- Zinnia Politzer
- Poker Winner
- David Pridemore
- FBI Agent
- Suzanne Prunty
- Driver
- Curtis Reid
- Club-Goer
- Erin Reinhard
- Club Patron
- Brandon Richardson
- Factory Worker
- Matt Rouillard
- ER Orderly
- Billy Silvia
- Police Officer
- Richard Spink
- FBI Agent
- Michael Stanton
- Boston Police Detective
- David Struffolino
- Perp
- Ben Tanguay
- Club Patron
- Phil Tavares
- FBI SWAT
- Matt Theriault
- Nerd: Coin Collector
- Sam Vanivray
- Club Goer
- George J. Vezina
- Howard
